Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma

Diana Bell; Ehab Y. Hanna; Lucio Miele; Dianna Roberts; Randal S. Weber; Adel K. El-Naggar

doi:10.1016/j.anndiagpath.2013.10.001

Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma

Diana Bell, Ehab Y. Hanna, Lucio Miele, Dianna Roberts, Randal S. Weber, Adel K. El-Naggar

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.

Original language	English (US)
Pages (from-to)	10-13
Number of pages	4
Journal	Annals of Diagnostic Pathology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.anndiagpath.2013.10.001
State	Published - Feb 2014

Keywords

Adenoid cystic
Cancer stem cells
Carcinoma
Notch
Notch-2/Jagged-1
Targeted therapy

ASJC Scopus subject areas

Pathology and Forensic Medicine

MD Anderson CCSG core facilities

Clinical Trials Office

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10.1016/j.anndiagpath.2013.10.001

Cite this

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title = "Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma",

abstract = "Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.",

keywords = "Adenoid cystic, Cancer stem cells, Carcinoma, Notch, Notch-2/Jagged-1, Targeted therapy",

author = "Diana Bell and Hanna, {Ehab Y.} and Lucio Miele and Dianna Roberts and Weber, {Randal S.} and El-Naggar, {Adel K.}",

note = "Funding Information: Adenoid cystic carcinoma tissue microarrays were constructed and provided by Dr Adel K. El-Naggar's laboratory ( the National Institute of Health, National Institute of Dental and Craniofacial Research and Rare Disease Research Grant No. UO1DE019765 [to AKE-N]). This study was supported in part by MDACC start-up funds (to D.B.).",

year = "2014",

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doi = "10.1016/j.anndiagpath.2013.10.001",

language = "English (US)",

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journal = "Annals of Diagnostic Pathology",

issn = "1092-9134",

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AU - Bell, Diana

AU - Hanna, Ehab Y.

AU - Miele, Lucio

AU - Roberts, Dianna

AU - Weber, Randal S.

AU - El-Naggar, Adel K.

N1 - Funding Information: Adenoid cystic carcinoma tissue microarrays were constructed and provided by Dr Adel K. El-Naggar's laboratory ( the National Institute of Health, National Institute of Dental and Craniofacial Research and Rare Disease Research Grant No. UO1DE019765 [to AKE-N]). This study was supported in part by MDACC start-up funds (to D.B.).

PY - 2014/2

Y1 - 2014/2

N2 - Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.

AB - Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.

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KW - Cancer stem cells

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KW - Notch-2/Jagged-1

KW - Targeted therapy

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Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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