Abstract
Day 14 fetal thymocytes and adult dendritic epidermal T cells (dEC) of all mouse strains express a characteristic non-polymorphic γδ T-cell receptor which is rarely found in the adult thymus or lymph nodes. We have made transgenic mice expressing this particular set of receptors on T cells in C3H and C57BL/6 mice. In adult mice of the latter strain, a dramatic depletion of transgene expressing T cells occurs and this effect is primarily mediated by thymic radiosensitive cells. The depletion is genetically dominant but not MHC-linked with major factor(s) mapping to chromosome 18. Taken together, our results show that strain-specific developmental changes in the thymic environment may play a role in shaping the γδ TCR repertoire.
Original language | English (US) |
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Pages (from-to) | 385-393 |
Number of pages | 9 |
Journal | International immunology |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1991 |
Externally published | Yes |
Keywords
- Non-MHC-linked selective depletion
- γδ T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology