TY - JOUR
T1 - Expression of androgen receptor and prostate-specific antigen in male breast carcinoma
AU - Kidwai, Noman
AU - Gong, Yun
AU - Sun, Xiaoping
AU - Deshpande, Charuhas G.
AU - Yeldandi, Anjana V.
AU - Rao, M. Sambasiva
AU - Badve, Sunil
N1 - Publisher Copyright:
© 2004 Kidwai et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
PY - 2003/11/7
Y1 - 2003/11/7
N2 - Background: The androgen-regulated proteins prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are present in high concentrations in normal prostate and prostatic cancer and are considered to be tissue-specific to prostate. These markers are commonly used to diagnose metastatic prostate carcinoma at various sites including the male breast. However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated. Methods: In this study we analyzed the expression of PSA, PSAP and androgen receptor (AR) by immunohistochemistry in 26 cases of male breast carcinomas and correlated these with the expression of other prognostic markers. Results: AR, PSA and PSAP expression was observed in 81%, 23% and 0% of carcinomas, respectively. Combined expression of AR and PSA was observed in only four tumors. Conclusion: Although the biological significance of PSA expression in male breast carcinomas is not clear, caution should be exercised when it is used as a diagnostic marker of metastatic prostate carcinoma.
AB - Background: The androgen-regulated proteins prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are present in high concentrations in normal prostate and prostatic cancer and are considered to be tissue-specific to prostate. These markers are commonly used to diagnose metastatic prostate carcinoma at various sites including the male breast. However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated. Methods: In this study we analyzed the expression of PSA, PSAP and androgen receptor (AR) by immunohistochemistry in 26 cases of male breast carcinomas and correlated these with the expression of other prognostic markers. Results: AR, PSA and PSAP expression was observed in 81%, 23% and 0% of carcinomas, respectively. Combined expression of AR and PSA was observed in only four tumors. Conclusion: Although the biological significance of PSA expression in male breast carcinomas is not clear, caution should be exercised when it is used as a diagnostic marker of metastatic prostate carcinoma.
KW - Androgen receptor
KW - Immunohistochemistry
KW - Male breast carcinoma
KW - Prostate-specific antigen
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U2 - 10.1186/bcr733
DO - 10.1186/bcr733
M3 - Article
C2 - 14680496
AN - SCOPUS:85010735708
SN - 1465-5411
VL - 6
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - R18
ER -