Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids

William F. Benedict; Betty Paul; Daniel W. Nebert

doi:10.1016/S0006-291X(72)80049-4

Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids

William F. Benedict, Betty Paul, Daniel W. Nebert

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Aryl hydrocarbon hydroxylase (AHH) activity is inducible in mouse 3T3 fibroblasts by benz[a]anthracene, whereas no detectable basal or inducible levels occur in hamster BHK cells and barely detectable inducible levels of this enzyme are found in human D98 cultures. AHH induction is present-at about the same degree as that in the mouse parent line-in 6 of 9 mouse-hamster hybrids and in 3 of 3 mouse-human hybrids. AHH induction is gene-dose dependent in the only mouse-hamster clone having an excess of mouse chromosomes.

Original language	English (US)
Pages (from-to)	293-298
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(72)80049-4
State	Published - Jul 25 1972

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Aryl hydrocarbon hydroxylase (AHH) activity is inducible in mouse 3T3 fibroblasts by benz[a]anthracene, whereas no detectable basal or inducible levels occur in hamster BHK cells and barely detectable inducible levels of this enzyme are found in human D98 cultures. AHH induction is present-at about the same degree as that in the mouse parent line-in 6 of 9 mouse-hamster hybrids and in 3 of 3 mouse-human hybrids. AHH induction is gene-dose dependent in the only mouse-hamster clone having an excess of mouse chromosomes.",

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AU - Paul, Betty

AU - Nebert, Daniel W.

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Y1 - 1972/7/25

N2 - Aryl hydrocarbon hydroxylase (AHH) activity is inducible in mouse 3T3 fibroblasts by benz[a]anthracene, whereas no detectable basal or inducible levels occur in hamster BHK cells and barely detectable inducible levels of this enzyme are found in human D98 cultures. AHH induction is present-at about the same degree as that in the mouse parent line-in 6 of 9 mouse-hamster hybrids and in 3 of 3 mouse-human hybrids. AHH induction is gene-dose dependent in the only mouse-hamster clone having an excess of mouse chromosomes.

AB - Aryl hydrocarbon hydroxylase (AHH) activity is inducible in mouse 3T3 fibroblasts by benz[a]anthracene, whereas no detectable basal or inducible levels occur in hamster BHK cells and barely detectable inducible levels of this enzyme are found in human D98 cultures. AHH induction is present-at about the same degree as that in the mouse parent line-in 6 of 9 mouse-hamster hybrids and in 3 of 3 mouse-human hybrids. AHH induction is gene-dose dependent in the only mouse-hamster clone having an excess of mouse chromosomes.

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Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids

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