TY - JOUR
T1 - Expression of CD34 in sclerotic ('plywood') fibromas
AU - Hanft, Valerie N.
AU - Shea, Christopher R.
AU - McNutt, N. Scott
AU - Pullitzer, Donald
AU - Horenstein, Marcelo G.
AU - Prieto, Victor G.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - CD34 antigen is expressed in normal human skin on endothelium, in spindle cells located around adnexal structures and in a subset of interstitial cells in the reticular dermis. CD34 expression has also been identified in a number of fibrohistiocytic neoplasms, such as dermatofibrosarcoma protuberans and solitary fibrous tumors of soft tissue. CD34 expression has not previously been described in sclerotic, or 'plywood' fibromas. Here presented are three lesions from three patients, in which histologic examination revealed a well-circumscribed dermal nodule composed of spindled cells with focal nuclear pseudoinclusions. There was extensive fibrosis with hypocellular, storiform areas, characteristic of sclerotic fibroma. The spindled cells strongly expressed CD34, but not factor XIIIa or markers of melanocytic, neural, or muscular differentiation. A diagnosis of Cowden syndrome was considered in one of the cases. These cases provide evidence that CD34 expression can occur in sclerotic fibromas, either solitary or associated with Cowden syndrome. When diagnosing a sclerotic fibroma, one should comment in the report regarding the possibility of Cowden syndrome.
AB - CD34 antigen is expressed in normal human skin on endothelium, in spindle cells located around adnexal structures and in a subset of interstitial cells in the reticular dermis. CD34 expression has also been identified in a number of fibrohistiocytic neoplasms, such as dermatofibrosarcoma protuberans and solitary fibrous tumors of soft tissue. CD34 expression has not previously been described in sclerotic, or 'plywood' fibromas. Here presented are three lesions from three patients, in which histologic examination revealed a well-circumscribed dermal nodule composed of spindled cells with focal nuclear pseudoinclusions. There was extensive fibrosis with hypocellular, storiform areas, characteristic of sclerotic fibroma. The spindled cells strongly expressed CD34, but not factor XIIIa or markers of melanocytic, neural, or muscular differentiation. A diagnosis of Cowden syndrome was considered in one of the cases. These cases provide evidence that CD34 expression can occur in sclerotic fibromas, either solitary or associated with Cowden syndrome. When diagnosing a sclerotic fibroma, one should comment in the report regarding the possibility of Cowden syndrome.
KW - CD34
KW - Cowden syndrome
KW - Immunohistochemistry
KW - Sclerotic fibroma
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U2 - 10.1097/00000372-200002000-00003
DO - 10.1097/00000372-200002000-00003
M3 - Article
C2 - 10698210
AN - SCOPUS:0033970309
SN - 0193-1091
VL - 22
SP - 17
EP - 21
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 1
ER -