Abstract
The pre-B lymphoma-prone inbred strain SL/Kh mice showed a polyclonal expansion of BP-1+ pre-B cells in bone marrow early in life. Preneoplastic pre-B cells did not express adhesion molecules LECAM-1 and LFA-1, whereas neoplastic pre-B cells consistently expressed both molecules. There were two types of pre-B lymphomas in SL/Kh with distinct in vivo behavior. One infiltrated lymph nodes and spleen and another, predominantly bone marrow. However, lymphoma cells of both types expressed BP-1, LECAM-1 and LFA-1. Expression of these adhesion molecules on BP-1+ cells, therefore, may represent an important consequence of pre-B lymphomagenesis in SL/Kh strain, but is not sufficient to explain the in vivo behavior of the pre-B lymphoma cells.
Original language | English (US) |
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Pages (from-to) | 337-342 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1997 |
Keywords
- B cell differentiation
- Homing
- LECAM-1
- LFA-1
- Pre-B lymphoma
- Preneoplastic change
- SL/Kh mice
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research