Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors

L. D. Teeter, H. C. Hsu, S. A. Curley, M. J. Tong, M. Tien Kuo

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11 Citations (Scopus)

Abstract

Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDP) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalInternational Journal of Oncology
Volume2
Issue number1
StatePublished - 1993

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Multiple Drug Resistance
P-Glycoprotein
Hepatocellular Carcinoma
Neoplasm Metastasis
Liver
MDR Genes
Genes
Neoplasms
Colon
P-Glycoproteins
Liver Neoplasms
Ribonucleases
Drug Resistance

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors. / Teeter, L. D.; Hsu, H. C.; Curley, S. A.; Tong, M. J.; Tien Kuo, M.

In: International Journal of Oncology, Vol. 2, No. 1, 1993, p. 73-80.

Research output: Contribution to journalArticle

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AU - Tong, M. J.

AU - Tien Kuo, M.

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