Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors

L. D. Teeter; H. C. Hsu; S. A. Curley; M. J. Tong; M. Tien Kuo

doi:10.3892/ijo.2.1.73

Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors

L. D. Teeter, H. C. Hsu, S. A. Curley, M. J. Tong, M. Tien Kuo

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDP) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.

Original language	English (US)
Pages (from-to)	73-80
Number of pages	8
Journal	International journal of oncology
Volume	2
Issue number	1
DOIs	https://doi.org/10.3892/ijo.2.1.73
State	Published - 1993

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors",

abstract = "Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDP) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.",

author = "Teeter, {L. D.} and Hsu, {H. C.} and Curley, {S. A.} and Tong, {M. J.} and {Tien Kuo}, M.",

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T1 - Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors

AU - Teeter, L. D.

AU - Hsu, H. C.

AU - Curley, S. A.

AU - Tong, M. J.

AU - Tien Kuo, M.

PY - 1993

Y1 - 1993

N2 - Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDP) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.

AB - Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDP) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.

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Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors

Abstract

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