Expression of protease-activated receptor 1 in oral squamous cell carcinoma

Yanna Liu; Michael Z. Gilcrease; Ying Henderson; Xiao H. Yuan; Gary L. Clayman; Zhuo Chen

doi:10.1016/S0304-3835(01)00504-3

Expression of protease-activated receptor 1 in oral squamous cell carcinoma

Yanna Liu, Michael Z. Gilcrease, Ying Henderson, Xiao H. Yuan, Gary L. Clayman, Zhuo Chen

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.

Original language	English (US)
Pages (from-to)	173-180
Number of pages	8
Journal	Cancer Letters
Volume	169
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(01)00504-3
State	Published - Aug 28 2001

Keywords

Matrix metalloproteinase
Metastasis
Protease-activated receptor
Squamous cell carcinoma
Thrombin

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(01)00504-3

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title = "Expression of protease-activated receptor 1 in oral squamous cell carcinoma",

abstract = "Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.",

keywords = "Matrix metalloproteinase, Metastasis, Protease-activated receptor, Squamous cell carcinoma, Thrombin",

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T1 - Expression of protease-activated receptor 1 in oral squamous cell carcinoma

AU - Liu, Yanna

AU - Gilcrease, Michael Z.

AU - Henderson, Ying

AU - Yuan, Xiao H.

AU - Clayman, Gary L.

AU - Chen, Zhuo

PY - 2001/8/28

Y1 - 2001/8/28

N2 - Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.

AB - Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.

KW - Matrix metalloproteinase

KW - Metastasis

KW - Protease-activated receptor

KW - Squamous cell carcinoma

KW - Thrombin

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JF - Cancer Letters

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ER -

Expression of protease-activated receptor 1 in oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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