Abstract
A series of multidrug-resistant (MDR) Chinese hamster ovary (CHO) cells was established to survive in stepwise increasing concentrations of vincristine. These MDR cells contained amplified P-glycoprotein (mdr) genes. Using monoclonal antibody against the P-glycoprotein, we present here results showing that the levels of P-glycoprotein and its phosphorylation and glycosylation did not correlate with those of drug resistance. Our results suggest that overproduction of the P-glycoprotein cannot account for the differences in drug resistance in these MDR cells, and that multiple modalities are involved in multiple drug resistance in mammalian cells.
Original language | English (US) |
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Pages (from-to) | 575-578 |
Number of pages | 4 |
Journal | Anticancer research |
Volume | 9 |
Issue number | 3 |
State | Published - 1989 |
ASJC Scopus subject areas
- Oncology
- Cancer Research