Abstract
We investigated the changes in transforming growth factor β1 (TGF- β1) mRNA and TGF-β3 protein expression that occur in radiation interstitial pneumonitis. We used TGF-β1-cDNA probe in situ hybridization and TGF-β3 polyclonal antibody in immunohistochemical techniques. Our results showed that the distribution of TGF-β1 mRNA and TGF-β3 protein basically coincided in blood vessels, airways, lung parenchyma, and alveolar macrophages. However, bronchial epithelial cells expressed only TGF-β3 proteins and no TGF-β1 mRNA. We found an increased expression of TGF-β1 mRNA and TGF-β3 proteins in radiation interstitial pneumonitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-20 |
| Number of pages | 6 |
| Journal | Journal of Environmental Pathology, Toxicology and Oncology |
| Volume | 16 |
| Issue number | 1 |
| State | Published - 1997 |
| Externally published | Yes |
Keywords
- Radiation interstitial pneumonitis (RIP)
- Transforming growth factor β
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Health, Toxicology and Mutagenesis