Extensive survey of STAT6 expression in a large series of mesenchymal tumors

Elizabeth G. Demicco; Paul W. Harms; Rajiv M. Patel; Steven C. Smith; Davis Ingram; Keila Torres; Shannon L. Carskadon; Sandra Camelo-Piragua; Jonathan B. McHugh; Javed Siddiqui; Nallasivam Palanisamy; David R. Lucas; Alexander J. Lazar; Wei Lien Wang

doi:10.1309/AJCPN25NJTOUNPNF

Extensive survey of STAT6 expression in a large series of mesenchymal tumors

Elizabeth G. Demicco, Paul W. Harms, Rajiv M. Patel, Steven C. Smith, Davis Ingram, Keila Torres, Shannon L. Carskadon, Sandra Camelo-Piragua, Jonathan B. McHugh, Javed Siddiqui, Nallasivam Palanisamy, David R. Lucas, Alexander J. Lazar, Wei Lien Wang

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression patterns in other mesenchymal lesions. Methods: We performed immunohistochemical studies against the C-terminus of STAT6 in tissue microarrays and whole sections, comprising 2366 mesenchymal lesions. Results: Strong nuclear STAT6 was expressed in 285 of 2,021 tumors, including 206 of 240 SFTs, 49 of 408 well-differentiated/dedifferentiated liposarcomas, eight of 65 unclassified sarcomas, and 14 of 184 desmoid tumors, among others. Expression in SFTs was predominately limited to the nucleus. Other positive tumors typically expressed both nuclear and cytoplasmic STAT6. Complete absence of STAT6 was most common in pleomorphic liposarcoma and alveolar soft part sarcoma (60% and 72% cases negative, respectively). Conclusions: Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance.

Original language	English (US)
Pages (from-to)	672-682
Number of pages	11
Journal	American journal of clinical pathology
Volume	143
Issue number	5
DOIs	https://doi.org/10.1309/AJCPN25NJTOUNPNF
State	Published - May 2015

Keywords

Immunohistochemistry
STAT6
Sarcoma
Solitary fibrous tumor

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/AJCPN25NJTOUNPNF

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Demicco, E. G., Harms, P. W., Patel, R. M., Smith, S. C., Ingram, D., Torres, K., Carskadon, S. L., Camelo-Piragua, S., McHugh, J. B., Siddiqui, J., Palanisamy, N., Lucas, D. R., Lazar, A. J., & Wang, W. L. (2015). Extensive survey of STAT6 expression in a large series of mesenchymal tumors. American journal of clinical pathology, 143(5), 672-682. https://doi.org/10.1309/AJCPN25NJTOUNPNF

Demicco, EG, Harms, PW, Patel, RM, Smith, SC, Ingram, D, Torres, K, Carskadon, SL, Camelo-Piragua, S, McHugh, JB, Siddiqui, J, Palanisamy, N, Lucas, DR, Lazar, AJ & Wang, WL 2015, 'Extensive survey of STAT6 expression in a large series of mesenchymal tumors', American journal of clinical pathology, vol. 143, no. 5, pp. 672-682. https://doi.org/10.1309/AJCPN25NJTOUNPNF

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title = "Extensive survey of STAT6 expression in a large series of mesenchymal tumors",

abstract = "Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression patterns in other mesenchymal lesions. Methods: We performed immunohistochemical studies against the C-terminus of STAT6 in tissue microarrays and whole sections, comprising 2366 mesenchymal lesions. Results: Strong nuclear STAT6 was expressed in 285 of 2,021 tumors, including 206 of 240 SFTs, 49 of 408 well-differentiated/dedifferentiated liposarcomas, eight of 65 unclassified sarcomas, and 14 of 184 desmoid tumors, among others. Expression in SFTs was predominately limited to the nucleus. Other positive tumors typically expressed both nuclear and cytoplasmic STAT6. Complete absence of STAT6 was most common in pleomorphic liposarcoma and alveolar soft part sarcoma (60% and 72% cases negative, respectively). Conclusions: Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance.",

keywords = "Immunohistochemistry, STAT6, Sarcoma, Solitary fibrous tumor",

author = "Demicco, {Elizabeth G.} and Harms, {Paul W.} and Patel, {Rajiv M.} and Smith, {Steven C.} and Davis Ingram and Keila Torres and Carskadon, {Shannon L.} and Sandra Camelo-Piragua and McHugh, {Jonathan B.} and Javed Siddiqui and Nallasivam Palanisamy and Lucas, {David R.} and Lazar, {Alexander J.} and Wang, {Wei Lien}",

note = "Publisher Copyright: {\textcopyright} American Society for Clinical Pathology.",

year = "2015",

month = may,

doi = "10.1309/AJCPN25NJTOUNPNF",

language = "English (US)",

volume = "143",

pages = "672--682",

journal = "American journal of clinical pathology",

issn = "0002-9173",

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T1 - Extensive survey of STAT6 expression in a large series of mesenchymal tumors

AU - Demicco, Elizabeth G.

AU - Harms, Paul W.

AU - Patel, Rajiv M.

AU - Smith, Steven C.

AU - Ingram, Davis

AU - Torres, Keila

AU - Carskadon, Shannon L.

AU - Camelo-Piragua, Sandra

AU - McHugh, Jonathan B.

AU - Siddiqui, Javed

AU - Palanisamy, Nallasivam

AU - Lucas, David R.

AU - Lazar, Alexander J.

AU - Wang, Wei Lien

PY - 2015/5

Y1 - 2015/5

N2 - Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression patterns in other mesenchymal lesions. Methods: We performed immunohistochemical studies against the C-terminus of STAT6 in tissue microarrays and whole sections, comprising 2366 mesenchymal lesions. Results: Strong nuclear STAT6 was expressed in 285 of 2,021 tumors, including 206 of 240 SFTs, 49 of 408 well-differentiated/dedifferentiated liposarcomas, eight of 65 unclassified sarcomas, and 14 of 184 desmoid tumors, among others. Expression in SFTs was predominately limited to the nucleus. Other positive tumors typically expressed both nuclear and cytoplasmic STAT6. Complete absence of STAT6 was most common in pleomorphic liposarcoma and alveolar soft part sarcoma (60% and 72% cases negative, respectively). Conclusions: Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance.

AB - Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression patterns in other mesenchymal lesions. Methods: We performed immunohistochemical studies against the C-terminus of STAT6 in tissue microarrays and whole sections, comprising 2366 mesenchymal lesions. Results: Strong nuclear STAT6 was expressed in 285 of 2,021 tumors, including 206 of 240 SFTs, 49 of 408 well-differentiated/dedifferentiated liposarcomas, eight of 65 unclassified sarcomas, and 14 of 184 desmoid tumors, among others. Expression in SFTs was predominately limited to the nucleus. Other positive tumors typically expressed both nuclear and cytoplasmic STAT6. Complete absence of STAT6 was most common in pleomorphic liposarcoma and alveolar soft part sarcoma (60% and 72% cases negative, respectively). Conclusions: Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance.

KW - Immunohistochemistry

KW - STAT6

KW - Sarcoma

KW - Solitary fibrous tumor

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Extensive survey of STAT6 expression in a large series of mesenchymal tumors

Abstract

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