TY - JOUR
T1 - Extracellular Vesicles and Acute Kidney Injury
T2 - Potential Therapeutic Avenue for Renal Repair and Regeneration
AU - Kosanović, Maja
AU - Milutinovic, Bojana
AU - Glamočlija, Sofija
AU - Morlans, Ingrid Mena
AU - Ortiz, Alberto
AU - Bozic, Milica
N1 - Funding Information:
This research was supported by a Miguel Servet research grant CP19/00027 from the Instituto de Salud Carlos III (ISCIII) and FEDER funds “Una manera de hacer Europa,” grants PI21/00204 and PI18/00292 from the ISCIII, cofinanciado por la Unión Europea, RICORS program to RICORS2040 (RD21/0005/0001) and SPACKDc PMP21/00109, REDINREN RD16/0009, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM, Instituto de Salud Carlos III. M.B. was supported by the Miguel Servet contract from the ISCIII (CP19/00027) financed by Fondo Social Europeo “El FSE invierte en tu future.” M.K. and S.G. were supported by a research grant from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No. 451-03-68/2022-14/200019).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular vesicles (EVs) are nanoparticles secreted by various cell types in both physiological and pathological conditions. EVs can arise from distinct parts of the kidney and can mediate intercellular communication between various cell types along the nephron. Besides their potential as diagnostic tools, EVs have been proposed as powerful new tools for regenerative medicine and have been broadly studied as therapeutic mediators in different models of experimental AKI. In this review, we present an overview of the basic features and biological relevance of EVs, with an emphasis on their functional role in cell-to-cell communication in the kidney. We explore versatile roles of EVs in crucial pathophysiological mechanisms contributing to AKI and give a detailed description of the renoprotective effects of EVs from different origins in AKI. Finally, we explain known mechanisms of action of EVs in AKI and provide an outlook on the potential clinical translation of EVs in the setting of AKI.
AB - Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular vesicles (EVs) are nanoparticles secreted by various cell types in both physiological and pathological conditions. EVs can arise from distinct parts of the kidney and can mediate intercellular communication between various cell types along the nephron. Besides their potential as diagnostic tools, EVs have been proposed as powerful new tools for regenerative medicine and have been broadly studied as therapeutic mediators in different models of experimental AKI. In this review, we present an overview of the basic features and biological relevance of EVs, with an emphasis on their functional role in cell-to-cell communication in the kidney. We explore versatile roles of EVs in crucial pathophysiological mechanisms contributing to AKI and give a detailed description of the renoprotective effects of EVs from different origins in AKI. Finally, we explain known mechanisms of action of EVs in AKI and provide an outlook on the potential clinical translation of EVs in the setting of AKI.
KW - acute kidney injury
KW - cell-free therapeutic
KW - cellular communication
KW - exosomes
KW - extracellular vesicles
KW - mesenchymal stem cells
KW - microvesicles
KW - renoprotection
KW - therapeutic agents
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U2 - 10.3390/ijms23073792
DO - 10.3390/ijms23073792
M3 - Review article
C2 - 35409151
AN - SCOPUS:85127246677
SN - 1661-6596
VL - 23
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 7
M1 - 3792
ER -