TY - JOUR
T1 - Extracellular vesicles
T2 - intelligent delivery strategies for therapeutic applications
AU - Pinheiro, Alice
AU - Silva, Andreia M.
AU - Teixeira, José H.
AU - Gonçalves, Raquel M.
AU - Almeida, Maria I.
AU - Barbosa, Mário A.
AU - Santos, Susana G.
N1 - Funding Information:
This work was supported by AO Foundation-Switzerland (project S-15-83S); and Project ( NORTE-01-0145-FEDER-000012 ) funded by Norte Portugal Regional Operational Programme ( NORTE 2020 ), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Programa Operacional Factores de Competitividade–COMPETE. MIA, JHT were supported by FCT – Fundação para a Ciência e a Tecnologia , through fellowships SFRH/BPD/91011/2012 , and SFRH/BD/112832/2015 . AMS was supported by NETDIAMOND_BI_03_2017 (in the scope of the project POCI-01-0145-FEDER- 016385).
Funding Information:
This work was supported by AO Foundation-Switzerland (project S-15-83S); and Project (NORTE-01-0145-FEDER-000012) funded by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Programa Operacional Factores de Competitividade–COMPETE. MIA, JHT were supported by FCT–Fundação para a Ciência e a Tecnologia, through fellowships SFRH/BPD/91011/2012, and SFRH/BD/112832/2015. AMS was supported by NETDIAMOND_BI_03_2017 (in the scope of the project POCI-01-0145-FEDER- 016385).
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/11/10
Y1 - 2018/11/10
N2 - Extracellular vesicles (EV), in particular exosomes, have been the object of intense research, due to their potential to mediate intercellular communication, modulating the phenotype of target cells. The natural properties and functions of EV are being exploited as biomarkers for disease diagnosis and prognosis, and as nano-bio-carriers for the development of new therapeutic strategies. EV have been particularly examined in the field of cancer, but are also increasingly investigated in other areas, like immune-related diseases and regenerative medicine. In this review, the therapeutic use of EV as drug delivery systems is described, balancing the advantages and drawbacks of different routes for their in vivo administration. Systemic and local delivery of EV are discussed, tackling the persisting difficulties in the assessment of their pharmacokinetics, pharmacodynamics and biodistribution in vivo. Finally, we discuss the future perspectives for incorporating EV into delivery systems and their use for an improved and controlled release of EV in vivo.
AB - Extracellular vesicles (EV), in particular exosomes, have been the object of intense research, due to their potential to mediate intercellular communication, modulating the phenotype of target cells. The natural properties and functions of EV are being exploited as biomarkers for disease diagnosis and prognosis, and as nano-bio-carriers for the development of new therapeutic strategies. EV have been particularly examined in the field of cancer, but are also increasingly investigated in other areas, like immune-related diseases and regenerative medicine. In this review, the therapeutic use of EV as drug delivery systems is described, balancing the advantages and drawbacks of different routes for their in vivo administration. Systemic and local delivery of EV are discussed, tackling the persisting difficulties in the assessment of their pharmacokinetics, pharmacodynamics and biodistribution in vivo. Finally, we discuss the future perspectives for incorporating EV into delivery systems and their use for an improved and controlled release of EV in vivo.
KW - Biodistribution
KW - Delivery system
KW - Exosomes
KW - Nanoparticles
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UR - http://www.scopus.com/inward/citedby.url?scp=85054037596&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2018.09.019
DO - 10.1016/j.jconrel.2018.09.019
M3 - Review article
C2 - 30261205
AN - SCOPUS:85054037596
SN - 0168-3659
VL - 289
SP - 56
EP - 69
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -