TY - JOUR
T1 - Extracolonic manifestations of hereditary colorectal cancer syndromes
AU - Anaya, Daniel A.
AU - Chang, George J.
AU - Rodriguez-Bigas, Miguel A.
PY - 2008/11
Y1 - 2008/11
N2 - Familial colorectal adenocarcinoma (CRC) accounts for ∼15 to 20% of CRC. Of these, hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) represent the most common hereditary syndromes associated with CRC, followed by other less common diseases including juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS). Extracolonic manifestations are common in each of these syndromes having significant implications for surveillance and management in at-risk individuals. The authors review the most common and clinically relevant extracolonic manifestations for each of these syndromes focusing on incidence, presentation, genotype/phenotype correlations, and management (including surveillance) strategies.
AB - Familial colorectal adenocarcinoma (CRC) accounts for ∼15 to 20% of CRC. Of these, hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) represent the most common hereditary syndromes associated with CRC, followed by other less common diseases including juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS). Extracolonic manifestations are common in each of these syndromes having significant implications for surveillance and management in at-risk individuals. The authors review the most common and clinically relevant extracolonic manifestations for each of these syndromes focusing on incidence, presentation, genotype/phenotype correlations, and management (including surveillance) strategies.
KW - Colorectal cancer
KW - Extracolonic manifestations
KW - Hereditary polyposis
UR - http://www.scopus.com/inward/record.url?scp=57149087280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57149087280&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1089941
DO - 10.1055/s-0028-1089941
M3 - Review article
C2 - 20011437
AN - SCOPUS:57149087280
SN - 1531-0043
VL - 21
SP - 263
EP - 272
JO - Clinics in Colon and Rectal Surgery
JF - Clinics in Colon and Rectal Surgery
IS - 4
ER -