Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand

H. Charles Manning; Timothy Goebel; John N. Marx; Darryl J. Bornhop

doi:10.1021/ol017155b

Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand

H. Charles Manning, Timothy Goebel, John N. Marx, Darryl J. Bornhop

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

matrix presented Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/ organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluorophore is described herein. The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers.

Original language	English (US)
Pages (from-to)	1075-1077
Number of pages	3
Journal	Organic Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1021/ol017155b
State	Published - Apr 4 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol017155b

Cite this

@article{04c7506fb4da44baaa7a56c680c5bc19,

title = "Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand",

abstract = "matrix presented Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/ organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluorophore is described herein. The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers.",

author = "Manning, {H. Charles} and Timothy Goebel and Marx, {John N.} and Bornhop, {Darryl J.}",

year = "2002",

month = apr,

day = "4",

doi = "10.1021/ol017155b",

language = "English (US)",

volume = "4",

pages = "1075--1077",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand

AU - Manning, H. Charles

AU - Goebel, Timothy

AU - Marx, John N.

AU - Bornhop, Darryl J.

PY - 2002/4/4

Y1 - 2002/4/4

N2 - matrix presented Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/ organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluorophore is described herein. The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers.

AB - matrix presented Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/ organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluorophore is described herein. The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers.

UR - http://www.scopus.com/inward/record.url?scp=0037018442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037018442&partnerID=8YFLogxK

U2 - 10.1021/ol017155b

DO - 10.1021/ol017155b

M3 - Article

C2 - 11922786

AN - SCOPUS:0037018442

SN - 1523-7060

VL - 4

SP - 1075

EP - 1077

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this