Abstract
We aimed to evaluate the feasibility of sentinel lymph node biopsy (SLNB) in multicentric/ multifocal breast cancer. In this prospective study, 23 women with multicentric/multifocal breast cancer underwent SLNB at our institution from April 2002 to February 2006. Presence of preoperative axillary metastases was confirmed by FNA. Patients underwent sub-areolar radiopharmaceutical injection ± isosulfan blue to perform SLNB, then completion ALND. The false-negative (FN) rate of SLNB was determined based upon final pathology. Twenty women with multicentric and three with multifocal invasive carcinoma were enrolled. The SLN identification rate was 100%. The overall FN rate of SLNB was 15% (95% Cl 0.0466, 0.4281). Both cases with FN SLNB had multicentric disease, pathologic stage III breast cancer and a larger tumor burden compared with the study population. SLNB using sub-areolar injection is feasible for patients with multicentric/multifocal breast cancer yet may be associated with a higher FN rate in patients with large additive tumor burden.
Original language | English (US) |
---|---|
Pages (from-to) | 645-648 |
Number of pages | 4 |
Journal | Breast Journal |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2009 |
Keywords
- Lymphoscintigraphy
- Multicentric breast cancer
- Multifocal breast cancer
- Sentinel lymph node biopsy
ASJC Scopus subject areas
- Internal Medicine
- Surgery
- Oncology