False-positive HIV nucleic acid amplification testing during CAR T-cell therapy

Ella J. Ariza-Heredia; Bruno P. Granwehr; George M. Viola; Micah Bhatti; James M. Kelley; James Kochenderfer; Chitra Hosing

doi:10.1016/j.diagmicrobio.2017.05.016

False-positive HIV nucleic acid amplification testing during CAR T-cell therapy

Ella J. Ariza-Heredia, Bruno P. Granwehr, George M. Viola, Micah Bhatti, James M. Kelley, James Kochenderfer, Chitra Hosing

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Advancements in immunotherapy have opened a new era in oncology, to include genetic modification of human T-cells to express a chimeric antigen receptor (CAR) that enables targeted tumor recognition (Kochenderfer et al., 2015; Lee et al., 2015; Maus and Levine 2016; Rosenberg et al., 2008). Herein, we report a false-positive HIV testing in a patient who had undergone CAR T-cell therapy created with a lentiviral vector.

Original language	English (US)
Pages (from-to)	305-307
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	88
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2017.05.016
State	Published - Aug 2017

Keywords

CAR T-cell therapy
False-positive
HIV
Immunotherapy

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2017.05.016

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title = "False-positive HIV nucleic acid amplification testing during CAR T-cell therapy",

abstract = "Advancements in immunotherapy have opened a new era in oncology, to include genetic modification of human T-cells to express a chimeric antigen receptor (CAR) that enables targeted tumor recognition (Kochenderfer et al., 2015; Lee et al., 2015; Maus and Levine 2016; Rosenberg et al., 2008). Herein, we report a false-positive HIV testing in a patient who had undergone CAR T-cell therapy created with a lentiviral vector.",

keywords = "CAR T-cell therapy, False-positive, HIV, Immunotherapy",

author = "Ariza-Heredia, {Ella J.} and Granwehr, {Bruno P.} and Viola, {George M.} and Micah Bhatti and Kelley, {James M.} and James Kochenderfer and Chitra Hosing",

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AU - Ariza-Heredia, Ella J.

AU - Granwehr, Bruno P.

AU - Viola, George M.

AU - Bhatti, Micah

AU - Kelley, James M.

AU - Kochenderfer, James

AU - Hosing, Chitra

PY - 2017/8

Y1 - 2017/8

N2 - Advancements in immunotherapy have opened a new era in oncology, to include genetic modification of human T-cells to express a chimeric antigen receptor (CAR) that enables targeted tumor recognition (Kochenderfer et al., 2015; Lee et al., 2015; Maus and Levine 2016; Rosenberg et al., 2008). Herein, we report a false-positive HIV testing in a patient who had undergone CAR T-cell therapy created with a lentiviral vector.

AB - Advancements in immunotherapy have opened a new era in oncology, to include genetic modification of human T-cells to express a chimeric antigen receptor (CAR) that enables targeted tumor recognition (Kochenderfer et al., 2015; Lee et al., 2015; Maus and Levine 2016; Rosenberg et al., 2008). Herein, we report a false-positive HIV testing in a patient who had undergone CAR T-cell therapy created with a lentiviral vector.

KW - CAR T-cell therapy

KW - False-positive

KW - HIV

KW - Immunotherapy

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False-positive HIV nucleic acid amplification testing during CAR T-cell therapy

Abstract

Keywords

ASJC Scopus subject areas

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