@article{18ab985e4e244c3687f981de591aaef9,
title = "Familial predisposition to wilms tumor does not segregate with the WT1 gene",
abstract = "Wilms tumor (WT) is one of the more common childhood cancers. A small fraction of WT occurs in association with aniridia, genitourinary abnormalities and mental retardation, the WAGR syndrome, and these cases often are accompanied by a constitutional deletion of all or part of band 11p13. Recently a WT susceptibility gene (WT1), localized to 11p13, has been isolated and shown to be inactivated in some sporadic WTs. In the present study, a highly informative CA repeat polymorphism within the gene was studied in a family with six affected members in three generations. Predisposition to WT in this large family did not segregate with this polymorphism. Furthermore, linkage analysis indicated exclusion of WT predisposition from 11p15. These results provide definitive evidence that familial predisposition to WT can be mediated by a gene other than WT1.",
author = "Schwartz, {C. E.} and Haber, {D. A.} and Stanton, {V. P.} and Strong, {L. C.} and Skolnick, {M. H.} and Housman, {D. E.}",
note = "Funding Information: We thank the family members for their cooperation over the long period of this investigation. We thank Drs. S. Hasstedt, T. McClellan, T. Bishop, D. Gerhard, and G. Bruns for their assistance in the early stages of this study, as well as Dr. David Bragg and members of the Department of Radiology, University of Utah Medical Center, for performing the ultrasound and IVP examina- tions. Technical assistance was provided by Nancy Kirschner, Tbao Tran, Kim Nguyen, and Ian Pancoast. Grant support was provided by NC1 and NIH to M.H.S. (CA48711), L.C.S. (CA34936), and D.E.H. (GM27882). D.A.H. was supported by National Cancer Institute Investigator Award lKOSCA01356. This work was supported, in part, by a grant from the South Carolina Department of Mental Retardation.",
year = "1991",
month = aug,
doi = "10.1016/0888-7543(91)90181-D",
language = "English (US)",
volume = "10",
pages = "927--930",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "4",
}