Abstract
Cytogenetic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocation (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example - the first two being retinoblastoma and Wilms' tumor - of a chromosomal deletion occurring germinally or somatically in association with a specific tumor. This finding adds further support to the existence of specific human cancer genes.
Original language | English (US) |
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Pages (from-to) | 939-941 |
Number of pages | 3 |
Journal | Science |
Volume | 217 |
Issue number | 4563 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- General