TY - JOUR
T1 - Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women
AU - Anderson, Kristin
AU - Thompson, Patricia A.
AU - Wertheim, Betsy C.
AU - Martin, Lorena
AU - Komenaka, Ian K.
AU - Bondy, Melissa
AU - Daneri-Navarro, Adrian
AU - Meza-Montenegro, Maria Mercedes
AU - Gutierrez-Millan, Luis Enrique
AU - Brewster, Abenaa
AU - Madlensky, Lisa
AU - Tobias, Malaika
AU - Natarajan, Loki
AU - Martínez, María Elena
N1 - Publisher Copyright:
© 2014, Anderson et al.; licensee Springer.
PY - 2014
Y1 - 2014
N2 - Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26–3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26–2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.
AB - Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26–3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26–2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.
KW - Family history
KW - Hispanic
KW - Risk factor heterogeneity
KW - Triple negative breast cancer
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U2 - 10.1186/2193-1801-3-727
DO - 10.1186/2193-1801-3-727
M3 - Article
C2 - 25713754
AN - SCOPUS:84923799539
SN - 2193-1801
VL - 3
JO - SpringerPlus
JF - SpringerPlus
IS - 1
ER -