Fast neutron radiotherapy: The university of Washington experience

Keith J. Stelzer, George E. Laramore, Thomas W. Griffin, Wui Jin Koh, Mary Austin-Seymour, Kenneth J. Russell, Thomas A. Buchholz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An overview of the University of Washington neutron radiotherapy facility is presented. The utility of the multi-leaf, programmable, variable collimator is emphasized. Due to success in the treatment of salivary gland tumors, such patients comprise an ever increasing portion of the patients being treated. A cooperative randomized clinical trial for the treatment of salivary gland tumors was undertaken comparing fast neutrons against photon/electron radiation. At ten years, there was a statistically significant improvement in local/regional control for the neutron group (56% vs 25% p = 0.009), but there was no improvement in survival (15% vs 25% p = n.s.). Distant metastases were the primary reason for the failure of improved local/regional control to impact survival in the neutron group. The University of Washington experience is summarized with special emphasis on the treatment of adenoid cystic carcinomas. Excellent local/regional control can be achieved with neutrons even for large tumors arising in the paranasal sinuses. We conclude that the potential morbidity of a surgical debulking procedure is not warranted in most clinical situations.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalActa Oncologica
Volume33
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Fast Neutrons
Neutrons
Radiotherapy
Glandular and Epithelial Neoplasms
Adenoid Cystic Carcinoma
Survival
Paranasal Sinuses
Photons
Therapeutics
Randomized Controlled Trials
Electrons
Radiation
Neoplasm Metastasis
Morbidity
Control Groups
Neoplasms

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Stelzer, K. J., Laramore, G. E., Griffin, T. W., Koh, W. J., Austin-Seymour, M., Russell, K. J., & Buchholz, T. A. (1994). Fast neutron radiotherapy: The university of Washington experience. Acta Oncologica, 33(3), 275-280. https://doi.org/10.3109/02841869409098417

Fast neutron radiotherapy : The university of Washington experience. / Stelzer, Keith J.; Laramore, George E.; Griffin, Thomas W.; Koh, Wui Jin; Austin-Seymour, Mary; Russell, Kenneth J.; Buchholz, Thomas A.

In: Acta Oncologica, Vol. 33, No. 3, 01.01.1994, p. 275-280.

Research output: Contribution to journalArticle

Stelzer, KJ, Laramore, GE, Griffin, TW, Koh, WJ, Austin-Seymour, M, Russell, KJ & Buchholz, TA 1994, 'Fast neutron radiotherapy: The university of Washington experience', Acta Oncologica, vol. 33, no. 3, pp. 275-280. https://doi.org/10.3109/02841869409098417
Stelzer KJ, Laramore GE, Griffin TW, Koh WJ, Austin-Seymour M, Russell KJ et al. Fast neutron radiotherapy: The university of Washington experience. Acta Oncologica. 1994 Jan 1;33(3):275-280. https://doi.org/10.3109/02841869409098417
Stelzer, Keith J. ; Laramore, George E. ; Griffin, Thomas W. ; Koh, Wui Jin ; Austin-Seymour, Mary ; Russell, Kenneth J. ; Buchholz, Thomas A. / Fast neutron radiotherapy : The university of Washington experience. In: Acta Oncologica. 1994 ; Vol. 33, No. 3. pp. 275-280.
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