Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator

Ernst S. Kooreman, Petra J. van Houdt, Marlies E. Nowee, Vivian W.J. van Pelt, Rob H.N. Tijssen, Eric S. Paulson, Oliver J. Gurney-Champion, Jihong Wang, Folkert Koetsveld, Laurens D. van Buuren, Leon C. ter Beek, Uulke A. van der Heide

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Systems for magnetic resonance (MR-) guided radiotherapy enable daily MR imaging of cancer patients during treatment, which is of interest for treatment response monitoring and biomarker discovery using quantitative MRI (qMRI). Here, the performance of a 1.5 T MR-linac regarding qMRI was assessed on phantoms. Additionally, we show the feasibility of qMRI in a prostate cancer patient on this system for the first time. Materials and methods: Four 1.5 T MR-linac systems from four institutes were included in this study. T 1 and T 2 relaxation times, and apparent diffusion coefficient (ADC) maps, as well as dynamic contrast enhanced (DCE) images were acquired. Bland–Altman statistics were used, and accuracy, repeatability, and reproducibility were determined. Results: Median accuracy for T 1 ranged over the four systems from 2.7 to 14.3%, for T 2 from 10.4 to 14.1%, and for ADC from 1.9 to 2.7%. For DCE images, the accuracy ranged from 12.8 to 35.8% for a gadolinium concentration of 0.5 mM and deteriorated for higher concentrations. Median short-term repeatability for T 1 ranged from 0.6 to 5.1%, for T 2 from 0.4 to 1.2%, and for ADC from 1.3 to 2.2%. DCE acquisitions showed a coefficient of variation of 0.1–0.6% in the signal intensity. Long-term repeatability was 1.8% for T 1 , 1.4% for T 2 , 1.7% for ADC, and 17.9% for DCE. Reproducibility was 11.2% for T 1 , 2.9% for T 2 , 2.2% for ADC, and 18.4% for DCE. Conclusion: These results indicate that qMRI on the Unity MR-linac is feasible, accurate, and repeatable which is promising for treatment response monitoring and treatment plan adaptation based on daily qMRI.

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalRadiotherapy and Oncology
Volume133
DOIs
StatePublished - Apr 1 2019

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Particle Accelerators
Magnetic Resonance Spectroscopy
Gadolinium
Therapeutics
Prostatic Neoplasms
Radiotherapy
Biomarkers
Neoplasms

Keywords

  • Functional MRI
  • MR-linac
  • Multicenter
  • Phantom
  • Prostate cancer
  • Quantitative MRI

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Kooreman, E. S., van Houdt, P. J., Nowee, M. E., van Pelt, V. W. J., Tijssen, R. H. N., Paulson, E. S., ... van der Heide, U. A. (2019). Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator. Radiotherapy and Oncology, 133, 156-162. https://doi.org/10.1016/j.radonc.2019.01.011

Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator. / Kooreman, Ernst S.; van Houdt, Petra J.; Nowee, Marlies E.; van Pelt, Vivian W.J.; Tijssen, Rob H.N.; Paulson, Eric S.; Gurney-Champion, Oliver J.; Wang, Jihong; Koetsveld, Folkert; van Buuren, Laurens D.; ter Beek, Leon C.; van der Heide, Uulke A.

In: Radiotherapy and Oncology, Vol. 133, 01.04.2019, p. 156-162.

Research output: Contribution to journalArticle

Kooreman, ES, van Houdt, PJ, Nowee, ME, van Pelt, VWJ, Tijssen, RHN, Paulson, ES, Gurney-Champion, OJ, Wang, J, Koetsveld, F, van Buuren, LD, ter Beek, LC & van der Heide, UA 2019, 'Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator', Radiotherapy and Oncology, vol. 133, pp. 156-162. https://doi.org/10.1016/j.radonc.2019.01.011
Kooreman ES, van Houdt PJ, Nowee ME, van Pelt VWJ, Tijssen RHN, Paulson ES et al. Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator. Radiotherapy and Oncology. 2019 Apr 1;133:156-162. https://doi.org/10.1016/j.radonc.2019.01.011
Kooreman, Ernst S. ; van Houdt, Petra J. ; Nowee, Marlies E. ; van Pelt, Vivian W.J. ; Tijssen, Rob H.N. ; Paulson, Eric S. ; Gurney-Champion, Oliver J. ; Wang, Jihong ; Koetsveld, Folkert ; van Buuren, Laurens D. ; ter Beek, Leon C. ; van der Heide, Uulke A. / Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator. In: Radiotherapy and Oncology. 2019 ; Vol. 133. pp. 156-162.
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T1 - Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator

AU - Kooreman, Ernst S.

AU - van Houdt, Petra J.

AU - Nowee, Marlies E.

AU - van Pelt, Vivian W.J.

AU - Tijssen, Rob H.N.

AU - Paulson, Eric S.

AU - Gurney-Champion, Oliver J.

AU - Wang, Jihong

AU - Koetsveld, Folkert

AU - van Buuren, Laurens D.

AU - ter Beek, Leon C.

AU - van der Heide, Uulke A.

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N2 - Purpose: Systems for magnetic resonance (MR-) guided radiotherapy enable daily MR imaging of cancer patients during treatment, which is of interest for treatment response monitoring and biomarker discovery using quantitative MRI (qMRI). Here, the performance of a 1.5 T MR-linac regarding qMRI was assessed on phantoms. Additionally, we show the feasibility of qMRI in a prostate cancer patient on this system for the first time. Materials and methods: Four 1.5 T MR-linac systems from four institutes were included in this study. T 1 and T 2 relaxation times, and apparent diffusion coefficient (ADC) maps, as well as dynamic contrast enhanced (DCE) images were acquired. Bland–Altman statistics were used, and accuracy, repeatability, and reproducibility were determined. Results: Median accuracy for T 1 ranged over the four systems from 2.7 to 14.3%, for T 2 from 10.4 to 14.1%, and for ADC from 1.9 to 2.7%. For DCE images, the accuracy ranged from 12.8 to 35.8% for a gadolinium concentration of 0.5 mM and deteriorated for higher concentrations. Median short-term repeatability for T 1 ranged from 0.6 to 5.1%, for T 2 from 0.4 to 1.2%, and for ADC from 1.3 to 2.2%. DCE acquisitions showed a coefficient of variation of 0.1–0.6% in the signal intensity. Long-term repeatability was 1.8% for T 1 , 1.4% for T 2 , 1.7% for ADC, and 17.9% for DCE. Reproducibility was 11.2% for T 1 , 2.9% for T 2 , 2.2% for ADC, and 18.4% for DCE. Conclusion: These results indicate that qMRI on the Unity MR-linac is feasible, accurate, and repeatable which is promising for treatment response monitoring and treatment plan adaptation based on daily qMRI.

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KW - Multicenter

KW - Phantom

KW - Prostate cancer

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