TY - JOUR
T1 - Feasibility of tomotherapy to reduce normal lung and cardiac toxicity for distal esophageal cancer compared to three-dimensional radiotherapy
AU - Nguyen, Nam P.
AU - Krafft, Shane P.
AU - Vinh-Hung, Vincent
AU - Vos, Paul
AU - Almeida, Fabio
AU - Jang, Siyoung
AU - Ceizyk, Misty
AU - Desai, Anand
AU - Davis, Rick
AU - Hamilton, Russ
AU - Modarresifar, Homayoun
AU - Abraham, Dave
AU - Smith-Raymond, Lexie
PY - 2011/12
Y1 - 2011/12
N2 - Purpose: To compare the effectiveness of tomotherapy and three-dimensional (3D) conformal radiotherapy to spare normal critical structures (spinal cord, lungs, and ventricles) from excessive radiation in patients with distal esophageal cancers. Materials and methods: A retrospective dosimetric study of nine patients who had advanced gastro-esophageal (GE) junction cancer (7) or thoracic esophageal cancer (2) extending into the distal esophagus. Two plans were created for each of the patients. A three-dimensional plan was constructed with either three (anteroposterior, right posterior oblique, and left posterior oblique) or four (right anterior oblique, left anterior oblique, right posterior oblique, and left posterior oblique) fields. The second plan was for tomotherapy. Doses were 45 Gy to the PTV with an integrated boost of 5 Gy for tomotherapy. Results: Mean lung dose was respectively 7.4 and 11.8 Gy (p = 0.004) for tomotherapy and 3D plans. Corresponding values were 12.4 and 18.3 Gy (p = 0.006) for cardiac ventricles. Maximum spinal cord dose was respectively 31.3 and 37.4 Gy (p < 0.007) for tomotherapy and 3D plans. Homogeneity index was two for both groups. Conclusions: Compared to 3D conformal radiotherapy, tomotherapy decreased significantly the amount of normal tissue irradiated and may reduce treatment toxicity for possible dose escalation in future prospective studies.
AB - Purpose: To compare the effectiveness of tomotherapy and three-dimensional (3D) conformal radiotherapy to spare normal critical structures (spinal cord, lungs, and ventricles) from excessive radiation in patients with distal esophageal cancers. Materials and methods: A retrospective dosimetric study of nine patients who had advanced gastro-esophageal (GE) junction cancer (7) or thoracic esophageal cancer (2) extending into the distal esophagus. Two plans were created for each of the patients. A three-dimensional plan was constructed with either three (anteroposterior, right posterior oblique, and left posterior oblique) or four (right anterior oblique, left anterior oblique, right posterior oblique, and left posterior oblique) fields. The second plan was for tomotherapy. Doses were 45 Gy to the PTV with an integrated boost of 5 Gy for tomotherapy. Results: Mean lung dose was respectively 7.4 and 11.8 Gy (p = 0.004) for tomotherapy and 3D plans. Corresponding values were 12.4 and 18.3 Gy (p = 0.006) for cardiac ventricles. Maximum spinal cord dose was respectively 31.3 and 37.4 Gy (p < 0.007) for tomotherapy and 3D plans. Homogeneity index was two for both groups. Conclusions: Compared to 3D conformal radiotherapy, tomotherapy decreased significantly the amount of normal tissue irradiated and may reduce treatment toxicity for possible dose escalation in future prospective studies.
KW - Distal esophageal cancer
KW - Normal tissue sparing
KW - Tomotherapy
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U2 - 10.1016/j.radonc.2011.07.015
DO - 10.1016/j.radonc.2011.07.015
M3 - Article
C2 - 21908064
AN - SCOPUS:81855201809
SN - 0167-8140
VL - 101
SP - 438
EP - 442
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 3
ER -