Abstract
Background/Aim: The purpose of this study is to investigate the prognostic significance of the pretreatment F-NLR score, which is based on fibrinogen (F) and neutrophil-to-lymphocyte ratio (NLR) in patients with advanced hypopharyngeal carcinoma (HPC). Materials and Methods: A total of 111 advanced HPC patients treated with radiotherapy, chemoradiotherapy, or bioradiotherapy were classified into three groups: F-NLR score of 2 (fibrinogen ≥341 mg/dl and NLR≥3.59), score of 1 (fibrinogen ≥341 mg/dl or NLR≥3.59), and score of 0 (fibrinogen <341 mg/dl and NLR<3.59). Results: F-NLR score of 2 was an independent prognostic factor for overall (OS) and progression-free survival (PFS) in patients with advanced HPC in the multivariate analysis. Both OS and PFS were significantly lower in patients with an F-NLR score of 2 than in those with an F-NLR score of 0. Conclusion: F-NLR score was useful to stratify patients to extract poor prognostic characteristics in patients with advanced HPC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5321-5330 |
| Number of pages | 10 |
| Journal | Anticancer research |
| Volume | 38 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2018 |
Keywords
- F-NLR score
- Hypopharyngeal squamous cell carcinoma
- Neutrophil-to-lymphocyte ratio
- Pretreatment biomarker
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research