Abstract
ST-elevation myocardial infarction (STEMI) is related to acute occlusion of a coronary artery by a fibrin-rich thrombus. Early reperfusion in STEMI reduces infarct size and improves prognosis. Acute reperfusion may be achieved with percutaneous coronary intervention (PCI) and/or fibrinolytic agents. When performed in a timely manner, primary PCI is the preferred method of reperfusion; however, due to logistic reasons, including lack of PCI-capable hospitals and delay in the first medical contact-to-balloon time, this simplified approach lacks universal applicability. Due to clinical efficacy and the ease of administration, fibrinolysis is still an important reperfusion modality in patients with STEMI who cannot have primary PCI within guideline-recommended time. This review focuses on the role of fibrinolysis in patients with STEMI.
Original language | English (US) |
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Pages (from-to) | 201-215 |
Number of pages | 15 |
Journal | Expert Review of Cardiovascular Therapy |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- ST-elevation myocardial infarction
- fibrinolysis
- percutaneous coronary intervention
- pharmacoinvasive strategy
- prehospital
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine