TY - JOUR
T1 - Fibroblasts in cancer
AU - Kalluri, Raghu
AU - Zeisberg, Michael
N1 - Funding Information:
The work from the author’s laboratories was supported by the National Institutes of Health (NIH) and the Center for Matrix Biology (R.K.). M.Z. is funded by a NIH training grant to BIDMC. We would like to extend our special thanks to H. Dvorak and M. A. Grant for critical reading of this manuscript.
PY - 2006/5
Y1 - 2006/5
N2 - Tumours are known as wounds that do not heal - this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
AB - Tumours are known as wounds that do not heal - this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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U2 - 10.1038/nrc1877
DO - 10.1038/nrc1877
M3 - Review article
C2 - 16572188
AN - SCOPUS:33646384428
SN - 1474-175X
VL - 6
SP - 392
EP - 401
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 5
ER -