Fine-needle aspiration biopsy of metastatic small cell carcinoma from extrapulmonary sites

Hyung Ju C Shin, Nancy P Caraway

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Like a pulmonary counterpart, extrapulmonary small cell carcinoma (SCC) is an aggressive tumor with a high rate of metastasis. Forty-nine fine- needle aspiration biopsies (FNABs) (36 patients) of various primary sites other than the lung diagnosed as metastatic SCC (including Merkel cell carcinoma) were reviewed. FNABs were derived from lymph nodes (20), liver (7), bone (2), breast (1), pancreas (1), and skin/soft tissue (18). Primary tumor sites included the prostate (14), skin (11; Merkel cell carcinoma), cervix (5), urinary bladder (3), urethra (1), ovary (1), and parotid (1). Aspirates revealed predominantly dispersed single tumor cells with occasional clustering. Tumor cells were small with scant cytoplasm, fine powdery chromatin, and inconspicuous nucleoli. Nuclear molding, mitotic figures, and apoptotic bodies were frequently observed. In four cases, findings from the FNABs were used to render the initial diagnosis of SCC. FNAB is useful for determining whether metastases contain a SCC component, a finding that may alter clinical management. Cytologically, SCC from different primary sites cannot be differentiated, and its distinction requires clinical and radiographic correlation.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalDiagnostic Cytopathology
Volume19
Issue number3
DOIs
StatePublished - Sep 1 1998

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Small Cell Carcinoma
Fine Needle Biopsy
Merkel Cell Carcinoma
Neoplasms
Neoplasm Metastasis
Lung
Skin
Urethra
Cellular Structures
Cervix Uteri
Chromatin
Cluster Analysis
Prostate
Pancreas
Ovary
Cytoplasm
Urinary Bladder
Breast
Lymph Nodes
Bone and Bones

Keywords

  • Extrapulmonary small cell carcinoma
  • Fine-needle aspiration biopsy
  • Merkel cell carcinoma
  • Metastasis

ASJC Scopus subject areas

  • Anatomy

Cite this

Fine-needle aspiration biopsy of metastatic small cell carcinoma from extrapulmonary sites. / Shin, Hyung Ju C; Caraway, Nancy P.

In: Diagnostic Cytopathology, Vol. 19, No. 3, 01.09.1998, p. 177-181.

Research output: Contribution to journalArticle

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