TY - JOUR
T1 - Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas
T2 - Diagnostic pitfalls and clinical considerations
AU - Klijanienko, Jerzy
AU - El-Naggar, Adel K.
AU - Vielh, Philippe
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/9
Y1 - 1999/9
N2 - Preoperative fine-needle samplings (FNS) of 26 histologically proven carcinoma ex pleomorphic adenomas (24 primary tumors and 2 local recurrences in 24 patients) were retrospectively reviewed in order to evaluate their cytologic characteristics. Histologically, 17 were high-grade and 9 were low- grade carcinomas; 10 carcinomas were intratumoral (in situ), and 16 were infiltrative. A cytologic diagnosis of malignancy was established in 13 (50%) cases, 2 (7.7%) were suspicious, and 11 (42.3%) were negative for malignancy (10 pleomorphic adenomas, 1 inflammation). The majority (76.5%) of high-grade carcinomas were correctly diagnosed by FNS, regardless of invasiveness. Paradoxically, most (77.8%) negative results were encountered in low-grade carcinomas. Accurate diagnosis of malignancy on FNS is achieved in high-grade tumors and low sensitivity may cause interpretative difficulties in low-grade tumors.
AB - Preoperative fine-needle samplings (FNS) of 26 histologically proven carcinoma ex pleomorphic adenomas (24 primary tumors and 2 local recurrences in 24 patients) were retrospectively reviewed in order to evaluate their cytologic characteristics. Histologically, 17 were high-grade and 9 were low- grade carcinomas; 10 carcinomas were intratumoral (in situ), and 16 were infiltrative. A cytologic diagnosis of malignancy was established in 13 (50%) cases, 2 (7.7%) were suspicious, and 11 (42.3%) were negative for malignancy (10 pleomorphic adenomas, 1 inflammation). The majority (76.5%) of high-grade carcinomas were correctly diagnosed by FNS, regardless of invasiveness. Paradoxically, most (77.8%) negative results were encountered in low-grade carcinomas. Accurate diagnosis of malignancy on FNS is achieved in high-grade tumors and low sensitivity may cause interpretative difficulties in low-grade tumors.
KW - Carcinoma ex pleomorphic adenoma
KW - Cytology
KW - Fine-needle sampling
KW - Malignant mixed tumor
KW - Salivary gland neoplasias
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U2 - 10.1002/(SICI)1097-0339(199909)21:3<163::AID-DC3>3.0.CO;2-2
DO - 10.1002/(SICI)1097-0339(199909)21:3<163::AID-DC3>3.0.CO;2-2
M3 - Article
C2 - 10450099
AN - SCOPUS:0032802607
SN - 8755-1039
VL - 21
SP - 163
EP - 166
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
IS - 3
ER -