FIP200, a key signaling node to coordinately regulate various cellular processes

Boyi Gan; Jun Lin Guan

doi:10.1016/j.cellsig.2007.10.021

FIP200, a key signaling node to coordinately regulate various cellular processes

Boyi Gan, Jun Lin Guan

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.

Original language	English (US)
Pages (from-to)	787-794
Number of pages	8
Journal	Cellular Signalling
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.cellsig.2007.10.021
State	Published - May 2008
Externally published	Yes

Keywords

Cell proliferation
Cell size control
Cell survival
FIP200
Signal transduction

ASJC Scopus subject areas

Cell Biology

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10.1016/j.cellsig.2007.10.021

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title = "FIP200, a key signaling node to coordinately regulate various cellular processes",

abstract = "A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.",

keywords = "Cell proliferation, Cell size control, Cell survival, FIP200, Signal transduction",

author = "Boyi Gan and Guan, {Jun Lin}",

note = "Funding Information: This work is supported by NIH grant GM52890 to JL Guan. We thank our colleagues Huijun Wei, Huaping Fan, Fei Liu, Chun-Chi Liang and Heui Jin Ho for critical reading and helpful suggestions. ",

year = "2008",

month = may,

doi = "10.1016/j.cellsig.2007.10.021",

language = "English (US)",

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T1 - FIP200, a key signaling node to coordinately regulate various cellular processes

AU - Gan, Boyi

AU - Guan, Jun Lin

N1 - Funding Information: This work is supported by NIH grant GM52890 to JL Guan. We thank our colleagues Huijun Wei, Huaping Fan, Fei Liu, Chun-Chi Liang and Heui Jin Ho for critical reading and helpful suggestions.

PY - 2008/5

Y1 - 2008/5

N2 - A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.

AB - A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.

KW - Cell proliferation

KW - Cell size control

KW - Cell survival

KW - FIP200

KW - Signal transduction

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DO - 10.1016/j.cellsig.2007.10.021

M3 - Review article

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AN - SCOPUS:39749119904

SN - 0898-6568

VL - 20

SP - 787

EP - 794

JO - Cellular Signalling

JF - Cellular Signalling

IS - 5

ER -

FIP200, a key signaling node to coordinately regulate various cellular processes

Abstract

Keywords

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