Abstract
The ergosterol-depleting antifungal fluconazole, when given at concentrations not affecting growth, inhibited pseudohyphal growth in Saccharomyces cerevisiae, a genetically tractable fungus closely related to the human pathogen Candida albicans. These results suggest that S. cerevisiae could serve as a useful genetic system to study the morphogenetic effects induced by azoles in pathogenic yeast. Copyright (C) 2000 S. Karger AG, Basel.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 100-103 |
| Number of pages | 4 |
| Journal | Chemotherapy |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2000 |
Keywords
- Candida albicans
- Fluconazole
- Morphogenesis
- Pseudohyphal growth
- Saccharomyces cerevisiae
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Drug Discovery
- Pharmacology (medical)
- Infectious Diseases