Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu; P. Thomas Vernier; H. Charles Manning; Sarah Salemi; Aimin Li; Cheryl M. Craft; Martin A. Gundersen; Darryl J. Bornhop

doi:10.1117/12.501033

Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, Darryl J. Bornhop

Research output: Contribution to journal › Conference article › peer-review

Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5141
DOIs	https://doi.org/10.1117/12.501033
State	Published - 2003
Externally published	Yes
Event	Diagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany Duration: Jun 24 2003 → Jun 25 2003

Keywords

Brain tumors diagnosis
Fluorescence microscopy
Lanthanide chelates fluorescence
Multi-modal imaging probes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.501033

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title = "Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging",

abstract = "This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.",

keywords = "Brain tumors diagnosis, Fluorescence microscopy, Lanthanide chelates fluorescence, Multi-modal imaging probes",

author = "Laura Marcu and Vernier, {P. Thomas} and Manning, {H. Charles} and Sarah Salemi and Aimin Li and Craft, {Cheryl M.} and Gundersen, {Martin A.} and Bornhop, {Darryl J.}",

year = "2003",

doi = "10.1117/12.501033",

language = "English (US)",

volume = "5141",

pages = "64--69",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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T1 - Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

AU - Marcu, Laura

AU - Vernier, P. Thomas

AU - Manning, H. Charles

AU - Salemi, Sarah

AU - Li, Aimin

AU - Craft, Cheryl M.

AU - Gundersen, Martin A.

AU - Bornhop, Darryl J.

PY - 2003

Y1 - 2003

N2 - This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

AB - This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

KW - Brain tumors diagnosis

KW - Fluorescence microscopy

KW - Lanthanide chelates fluorescence

KW - Multi-modal imaging probes

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UR - http://www.scopus.com/inward/citedby.url?scp=1342331821&partnerID=8YFLogxK

U2 - 10.1117/12.501033

DO - 10.1117/12.501033

M3 - Conference article

AN - SCOPUS:1342331821

SN - 0277-786X

VL - 5141

SP - 64

EP - 69

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Diagnostic Optical Spectroscopy in Biomedicine II

Y2 - 24 June 2003 through 25 June 2003

ER -

Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Abstract

Keywords

ASJC Scopus subject areas

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