Fluorinated graphene oxide; A new multimodal material for biological applications

Rebeca Romero-Aburto; Tharangattu N. Narayanan; Yutaka Nagaoka; Takashi Hasumura; Trevor M. Mitcham; Takahiro Fukuda; Paris J. Cox; Richard R. Bouchard; Toru Maekawa; D. Sakthi Kumar; Suzy V. Torti; Sendurai A. Mani; Pulickel M. Ajayan

doi:10.1002/adma201301804

Fluorinated graphene oxide; A new multimodal material for biological applications

Rebeca Romero-Aburto, Tharangattu N. Narayanan, Yutaka Nagaoka, Takashi Hasumura, Trevor M. Mitcham, Takahiro Fukuda, Paris J. Cox, Richard R. Bouchard, Toru Maekawa, D. Sakthi Kumar, Suzy V. Torti, Sendurai A. Mani, Pulickel M. Ajayan

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.

Original language	English (US)
Pages (from-to)	5632-5637
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	39
DOIs	https://doi.org/10.1002/adma201301804
State	Published - Oct 18 2013

Keywords

drug delivery
magnetic resonance imaging (MRI)
multifunctional graphene
photoacoustics
photothermal therapy

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility
Clinical Trials Office

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10.1002/adma201301804

Cite this

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title = "Fluorinated graphene oxide; A new multimodal material for biological applications",

abstract = "Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.",

keywords = "drug delivery, magnetic resonance imaging (MRI), multifunctional graphene, photoacoustics, photothermal therapy",

author = "Rebeca Romero-Aburto and Narayanan, {Tharangattu N.} and Yutaka Nagaoka and Takashi Hasumura and Mitcham, {Trevor M.} and Takahiro Fukuda and Cox, {Paris J.} and Bouchard, {Richard R.} and Toru Maekawa and Kumar, {D. Sakthi} and Torti, {Suzy V.} and Mani, {Sendurai A.} and Ajayan, {Pulickel M.}",

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doi = "10.1002/adma201301804",

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T1 - Fluorinated graphene oxide; A new multimodal material for biological applications

AU - Romero-Aburto, Rebeca

AU - Narayanan, Tharangattu N.

AU - Nagaoka, Yutaka

AU - Hasumura, Takashi

AU - Mitcham, Trevor M.

AU - Fukuda, Takahiro

AU - Cox, Paris J.

AU - Bouchard, Richard R.

AU - Maekawa, Toru

AU - Kumar, D. Sakthi

AU - Torti, Suzy V.

AU - Mani, Sendurai A.

AU - Ajayan, Pulickel M.

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.

AB - Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.

KW - drug delivery

KW - magnetic resonance imaging (MRI)

KW - multifunctional graphene

KW - photoacoustics

KW - photothermal therapy

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Fluorinated graphene oxide; A new multimodal material for biological applications

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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