TY - JOUR
T1 - Fluoroquinolone-Induced Seizure in a Patient Receiving End-of-Life Care
T2 - A Case Report
AU - Baez Gonzales, Joannis
AU - Clark, Matthew D.
AU - Bruera, Eduardo
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - When caring for patients nearing the end of live (EOL), healthcare providers must carefully assess the potential benefits and drawbacks of common medical interventions, such as starting antibiotic treatment. Antibiotic use during this stage can be a challenging and multifaceted situation, encompassing important clinical, social, and ethical considerations. While physicians may be motivated to prescribe antibiotics to terminally ill patients in hopes of prolonging survival and alleviating symptoms, it’s crucial to recognize that these drugs can have significant implications for individuals at the EOL. Factors like advanced age, frailty, and multiple medication use make these patients more vulnerable to adverse events caused by antibiotics. For instance, fluoroquinolones, a specific type of antibiotics, have been linked to central nervous system toxicity and neurological side effects, including seizures. Geriatric patients, who often have underlying risk factors, are particularly susceptible to fluoroquinolone-induced seizures. However, there have also been reports of otherwise healthy individuals experiencing seizures as a result of fluoroquinolone use. This report sheds light on the complexities associated with initiating antibiotic therapy in patients nearing the EOL.
AB - When caring for patients nearing the end of live (EOL), healthcare providers must carefully assess the potential benefits and drawbacks of common medical interventions, such as starting antibiotic treatment. Antibiotic use during this stage can be a challenging and multifaceted situation, encompassing important clinical, social, and ethical considerations. While physicians may be motivated to prescribe antibiotics to terminally ill patients in hopes of prolonging survival and alleviating symptoms, it’s crucial to recognize that these drugs can have significant implications for individuals at the EOL. Factors like advanced age, frailty, and multiple medication use make these patients more vulnerable to adverse events caused by antibiotics. For instance, fluoroquinolones, a specific type of antibiotics, have been linked to central nervous system toxicity and neurological side effects, including seizures. Geriatric patients, who often have underlying risk factors, are particularly susceptible to fluoroquinolone-induced seizures. However, there have also been reports of otherwise healthy individuals experiencing seizures as a result of fluoroquinolone use. This report sheds light on the complexities associated with initiating antibiotic therapy in patients nearing the EOL.
KW - antibiotics
KW - end-of-life care
KW - fluoroquinolone-induced seizures
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U2 - 10.1089/jpm.2023.0123
DO - 10.1089/jpm.2023.0123
M3 - Article
C2 - 37319353
AN - SCOPUS:85176926674
SN - 1096-6218
VL - 26
SP - 1590
EP - 1592
JO - Journal of palliative medicine
JF - Journal of palliative medicine
IS - 11
ER -