Formation of O6-Ethylthioethyldeoxyguanosine from the Reaction of Chloroethyl Ethyl Sulfide with Deoxyguanosine

David B. Ludlum; William P. Tong; Jitendra R. Mehta; Marion C. Kirk; Bruno Papirmeister

Formation of O6-Ethylthioethyldeoxyguanosine from the Reaction of Chloroethyl Ethyl Sulfide with Deoxyguanosine

David B. Ludlum, William P. Tong, Jitendra R. Mehta, Marion C. Kirk, Bruno Papirmeister

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

O⁶-Ethylthioethyldeoxyguanosine has been synthesized from 6-chloro-3',5' -di-O-acetyldeoxyguanosine and characterized by UV, fluorescence, and mass spectrometry. High-pressure liquid chromatography studies have shown that this modified nucleoside is formed when the one-armed sulfur mustard, chloroethyl ethyl sulfide, reacts with deoxyguanosine. This result supports the hypothesis that the mutagenic effects of the sulfur mustards are caused in part by substitution of the O⁶-position of deoxyguanosine.

Original language	English (US)
Pages (from-to)	5698-5701
Number of pages	4
Journal	Cancer Research
Volume	44
State	Published - Dec 1 1984

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Formation of O6-Ethylthioethyldeoxyguanosine from the Reaction of Chloroethyl Ethyl Sulfide with Deoxyguanosine",

abstract = "O6-Ethylthioethyldeoxyguanosine has been synthesized from 6-chloro-3',5' -di-O-acetyldeoxyguanosine and characterized by UV, fluorescence, and mass spectrometry. High-pressure liquid chromatography studies have shown that this modified nucleoside is formed when the one-armed sulfur mustard, chloroethyl ethyl sulfide, reacts with deoxyguanosine. This result supports the hypothesis that the mutagenic effects of the sulfur mustards are caused in part by substitution of the O6-position of deoxyguanosine.",

author = "Ludlum, {David B.} and Tong, {William P.} and Mehta, {Jitendra R.} and Kirk, {Marion C.} and Bruno Papirmeister",

year = "1984",

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language = "English (US)",

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T1 - Formation of O6-Ethylthioethyldeoxyguanosine from the Reaction of Chloroethyl Ethyl Sulfide with Deoxyguanosine

AU - Ludlum, David B.

AU - Tong, William P.

AU - Mehta, Jitendra R.

AU - Kirk, Marion C.

AU - Papirmeister, Bruno

PY - 1984/12/1

Y1 - 1984/12/1

N2 - O6-Ethylthioethyldeoxyguanosine has been synthesized from 6-chloro-3',5' -di-O-acetyldeoxyguanosine and characterized by UV, fluorescence, and mass spectrometry. High-pressure liquid chromatography studies have shown that this modified nucleoside is formed when the one-armed sulfur mustard, chloroethyl ethyl sulfide, reacts with deoxyguanosine. This result supports the hypothesis that the mutagenic effects of the sulfur mustards are caused in part by substitution of the O6-position of deoxyguanosine.

AB - O6-Ethylthioethyldeoxyguanosine has been synthesized from 6-chloro-3',5' -di-O-acetyldeoxyguanosine and characterized by UV, fluorescence, and mass spectrometry. High-pressure liquid chromatography studies have shown that this modified nucleoside is formed when the one-armed sulfur mustard, chloroethyl ethyl sulfide, reacts with deoxyguanosine. This result supports the hypothesis that the mutagenic effects of the sulfur mustards are caused in part by substitution of the O6-position of deoxyguanosine.

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AN - SCOPUS:0021726899

SN - 0008-5472

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JO - Cancer Research

JF - Cancer Research

ER -

Formation of O6-Ethylthioethyldeoxyguanosine from the Reaction of Chloroethyl Ethyl Sulfide with Deoxyguanosine

Abstract

ASJC Scopus subject areas

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