FoxO family members in cancer

Yuqing Zhang; Boyi Gan; Debra Liu; Ji Hye Paik

doi:10.4161/cbt.12.4.15954

FoxO family members in cancer

Yuqing Zhang, Boyi Gan, Debra Liu, Ji Hye Paik

Research output: Contribution to journal › Review article › peer-review

146 Scopus citations

Abstract

The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.

Original language	English (US)
Pages (from-to)	253-259
Number of pages	7
Journal	Cancer Biology and Therapy
Volume	12
Issue number	4
DOIs	https://doi.org/10.4161/cbt.12.4.15954
State	Published - Aug 15 2011
Externally published	Yes

Keywords

Cancer
FOXO
Feedback regulation
Homeostasis
RTK-PI3K-AKT-mTORC1
Survival
Therapeutic resistance
Tumor suppressor

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.4161/cbt.12.4.15954

Cite this

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title = "FoxO family members in cancer",

abstract = "The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.",

keywords = "Cancer, FOXO, Feedback regulation, Homeostasis, RTK-PI3K-AKT-mTORC1, Survival, Therapeutic resistance, Tumor suppressor",

author = "Yuqing Zhang and Boyi Gan and Debra Liu and Paik, {Ji Hye}",

note = "Funding Information: This work is supported by the Ellison Medical Foundation (AG-NS-0646-10 to J.H.P.) and the Department of Defense (PC100356 to B.G.).",

year = "2011",

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doi = "10.4161/cbt.12.4.15954",

language = "English (US)",

volume = "12",

pages = "253--259",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Landes Bioscience",

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T1 - FoxO family members in cancer

AU - Zhang, Yuqing

AU - Gan, Boyi

AU - Liu, Debra

AU - Paik, Ji Hye

N1 - Funding Information: This work is supported by the Ellison Medical Foundation (AG-NS-0646-10 to J.H.P.) and the Department of Defense (PC100356 to B.G.).

PY - 2011/8/15

Y1 - 2011/8/15

N2 - The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.

AB - The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.

KW - Cancer

KW - FOXO

KW - Feedback regulation

KW - Homeostasis

KW - RTK-PI3K-AKT-mTORC1

KW - Survival

KW - Therapeutic resistance

KW - Tumor suppressor

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DO - 10.4161/cbt.12.4.15954

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EP - 259

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 4

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FoxO family members in cancer

Abstract

Keywords

ASJC Scopus subject areas

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