FoxO transcription factors in cancer metabolism

Raj Kumar Yadav; Anoop Singh Chauhan; Li Zhuang; Boyi Gan

doi:10.1016/j.semcancer.2018.01.004

FoxO transcription factors in cancer metabolism

Raj Kumar Yadav, Anoop Singh Chauhan, Li Zhuang, Boyi Gan

Research output: Contribution to journal › Review article › peer-review

87 Scopus citations

Abstract

FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.

Original language	English (US)
Pages (from-to)	65-76
Number of pages	12
Journal	Seminars in cancer biology
Volume	50
DOIs	https://doi.org/10.1016/j.semcancer.2018.01.004
State	Published - Jun 2018

Keywords

Cancer metabolism
FoxO
Myc
Tumor suppression
mTOR

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2018.01.004

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title = "FoxO transcription factors in cancer metabolism",

abstract = "FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.",

keywords = "Cancer metabolism, FoxO, Myc, Tumor suppression, mTOR",

author = "Yadav, {Raj Kumar} and Chauhan, {Anoop Singh} and Li Zhuang and Boyi Gan",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = jun,

doi = "10.1016/j.semcancer.2018.01.004",

language = "English (US)",

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T1 - FoxO transcription factors in cancer metabolism

AU - Yadav, Raj Kumar

AU - Chauhan, Anoop Singh

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2018/6

Y1 - 2018/6

N2 - FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.

AB - FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.

KW - Cancer metabolism

KW - FoxO

KW - Myc

KW - Tumor suppression

KW - mTOR

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DO - 10.1016/j.semcancer.2018.01.004

M3 - Review article

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SN - 1044-579X

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SP - 65

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JO - Seminars in cancer biology

JF - Seminars in cancer biology

ER -

FoxO transcription factors in cancer metabolism

Abstract

Keywords

ASJC Scopus subject areas

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