Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

Masahiro Aihara; Luan D. Truong; J. Kay Dunn; Thomas M. Wheeler; Peter T. Scardino; Tomothy C. Thompson

doi:10.1016/0046-8177(94)90249-6

Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

Masahiro Aihara, Luan D. Truong, J. Kay Dunn, Thomas M. Wheeler, Peter T. Scardino, Tomothy C. Thompson

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.

Original language	English (US)
Pages (from-to)	797-801
Number of pages	5
Journal	Human Pathology
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/0046-8177(94)90249-6
State	Published - Aug 1994
Externally published	Yes

Keywords

Gleason grade
apoptosis
apoptotic body
prostate cancer

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1016/0046-8177(94)90249-6

Cite this

@article{d8b20aee07b0451bb1925f1eb8db9d27,

title = "Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer",

abstract = "Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.",

keywords = "Gleason grade, apoptosis, apoptotic body, prostate cancer",

author = "Masahiro Aihara and Truong, {Luan D.} and Dunn, {J. Kay} and Wheeler, {Thomas M.} and Scardino, {Peter T.} and Thompson, {Tomothy C.}",

note = "Funding Information: From the Scott Department of Urology, Department of Cell Biology, Department of Design Analysis, Baylor College of Medicine; Department of Pathology, The Methodist Hospital; and the Urology Research Laboratory, Veterans Affairs Medical Center, Houston, TX. Accepted for publication Februaty 21, 1994. Supported by grants no. CA50588 and SPORE P5O-CA58204 from the National Cancer Institute, Bethesda, MD, and in part by the Veterans Administration, Wilmington, DE. Keyw ords:a poptosis, apoptotic body, Gleason grade, prostate cancer. Address correspondence and reprint requests to Timothy C. Thompson, PbD, 6535 Fannin, F427A, Houston, TX 77030. Copyright 0 1994 by W.B. Saunders Company 0046-8177/94/250&0011$5.00/0",

year = "1994",

month = aug,

doi = "10.1016/0046-8177(94)90249-6",

language = "English (US)",

volume = "25",

pages = "797--801",

journal = "Human Pathology",

issn = "0046-8177",

publisher = "W.B. Saunders Ltd",

number = "8",

}

TY - JOUR

T1 - Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

AU - Aihara, Masahiro

AU - Truong, Luan D.

AU - Dunn, J. Kay

AU - Wheeler, Thomas M.

AU - Scardino, Peter T.

AU - Thompson, Tomothy C.

N1 - Funding Information: From the Scott Department of Urology, Department of Cell Biology, Department of Design Analysis, Baylor College of Medicine; Department of Pathology, The Methodist Hospital; and the Urology Research Laboratory, Veterans Affairs Medical Center, Houston, TX. Accepted for publication Februaty 21, 1994. Supported by grants no. CA50588 and SPORE P5O-CA58204 from the National Cancer Institute, Bethesda, MD, and in part by the Veterans Administration, Wilmington, DE. Keyw ords:a poptosis, apoptotic body, Gleason grade, prostate cancer. Address correspondence and reprint requests to Timothy C. Thompson, PbD, 6535 Fannin, F427A, Houston, TX 77030. Copyright 0 1994 by W.B. Saunders Company 0046-8177/94/250&0011$5.00/0

PY - 1994/8

Y1 - 1994/8

N2 - Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.

AB - Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.

KW - Gleason grade

KW - apoptosis

KW - apoptotic body

KW - prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=0027959046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027959046&partnerID=8YFLogxK

U2 - 10.1016/0046-8177(94)90249-6

DO - 10.1016/0046-8177(94)90249-6

M3 - Article

C2 - 7520020

AN - SCOPUS:0027959046

SN - 0046-8177

VL - 25

SP - 797

EP - 801

JO - Human Pathology

JF - Human Pathology

IS - 8

ER -

Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this