Abstract
Fruquintinib, a novel, highly selective, small-molecule tyrosine kinase inhibitor of VEGF receptors (VEGFRs)-1, -2 and -3, is approved in China for the treatment of metastatic colorectal cancer. FRESCO-2, a global, randomized, double-blind, placebo-controlled, Phase III study, is investigating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer. Key inclusion criteria include: progression on or intolerance to TAS-102 and/or regorafenib; and prior treatment with approved chemotherapy, anti-VEGF therapy, and, if RAS wild-type, anti-EGFR therapy. Approximately 687 patients will be randomized 2:1 to fruquintinib plus best supportive care or placebo plus best supportive care. Primary and key secondary end points are overall survival and progression-free survival, respectively. FRESCO-2 is enrolling in the USA, Europe, Australia and Japan.
Original language | English (US) |
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Pages (from-to) | 3151-3162 |
Number of pages | 12 |
Journal | Future Oncology |
Volume | 17 |
Issue number | 24 |
DOIs | |
State | Published - Aug 2021 |
Keywords
- Clinical development
- FRESCO-2
- Fruquintinib
- HMPL-013
- MCRC
- Phase III study
- Refractory metastatic colorectal cancer
- TKI
- VEGF
- VEGFR
ASJC Scopus subject areas
- Oncology
- Cancer Research