From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Y. David Seo; Jennifer A. Wargo

doi:10.1016/j.xcrm.2023.101039

From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Y. David Seo, Jennifer A. Wargo

Surgical Oncology

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Tintelnot et al.¹ identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

Original language	English (US)
Article number	101039
Journal	Cell Reports Medicine
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/j.xcrm.2023.101039
State	Published - May 16 2023

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.xcrm.2023.101039

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title = "From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer",

abstract = "Tintelnot et al.1 identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.",

author = "Seo, {Y. David} and Wargo, {Jennifer A.}",

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AU - Wargo, Jennifer A.

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N2 - Tintelnot et al.1 identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

AB - Tintelnot et al.1 identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

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JO - Cell Reports Medicine

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From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Abstract

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