From pituitary adenoma to pituitary neuroendocrine tumor (pitnet): An international pituitary pathology club proposal

S. L. Asa; O. Casar-Borota; P. Chanson; E. Delgrange; P. Earls; S. Ezzat; A. Grossman; H. Ikeda; N. Inoshita; N. Karavitaki; M. Korbonits; E. R. Laws; M. B. Lopes; N. Maartens; I. E. McCutcheon; O. Mete; H. Nishioka; G. Raverot; F. Roncaroli; W. Saeger; L. V. Syro; A. Vasiljevic; C. Villa; A. Wierinckx; J. Trouillas

doi:10.1530/ERC-17-0004

From pituitary adenoma to pituitary neuroendocrine tumor (pitnet): An international pituitary pathology club proposal

S. L. Asa, O. Casar-Borota, P. Chanson, E. Delgrange, P. Earls, S. Ezzat, A. Grossman, H. Ikeda, N. Inoshita, N. Karavitaki, M. Korbonits, E. R. Laws, M. B. Lopes, N. Maartens, I. E. McCutcheon, O. Mete, H. Nishioka, G. Raverot, F. Roncaroli, W. SaegerL. V. Syro, A. Vasiljevic, C. Villa, A. Wierinckx, J. Trouillas

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

251 Scopus citations

Abstract

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

Original language	English (US)
Pages (from-to)	C5-C8
Journal	Endocrine-related cancer
Volume	24
Issue number	4
DOIs	https://doi.org/10.1530/ERC-17-0004
State	Published - Apr 2017

Keywords

Nomenclature
Pituitary tumors

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Cancer Research

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10.1530/ERC-17-0004

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Asa, S. L., Casar-Borota, O., Chanson, P., Delgrange, E., Earls, P., Ezzat, S., Grossman, A., Ikeda, H., Inoshita, N., Karavitaki, N., Korbonits, M., Laws, E. R., Lopes, M. B., Maartens, N., McCutcheon, I. E., Mete, O., Nishioka, H., Raverot, G., Roncaroli, F., ... Trouillas, J. (2017). From pituitary adenoma to pituitary neuroendocrine tumor (pitnet): An international pituitary pathology club proposal. Endocrine-related cancer, 24(4), C5-C8. https://doi.org/10.1530/ERC-17-0004

Asa, SL, Casar-Borota, O, Chanson, P, Delgrange, E, Earls, P, Ezzat, S, Grossman, A, Ikeda, H, Inoshita, N, Karavitaki, N, Korbonits, M, Laws, ER, Lopes, MB, Maartens, N, McCutcheon, IE, Mete, O, Nishioka, H, Raverot, G, Roncaroli, F, Saeger, W, Syro, LV, Vasiljevic, A, Villa, C, Wierinckx, A & Trouillas, J 2017, 'From pituitary adenoma to pituitary neuroendocrine tumor (pitnet): An international pituitary pathology club proposal', Endocrine-related cancer, vol. 24, no. 4, pp. C5-C8. https://doi.org/10.1530/ERC-17-0004

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abstract = "The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.",

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AU - Asa, S. L.

AU - Casar-Borota, O.

AU - Chanson, P.

AU - Delgrange, E.

AU - Earls, P.

AU - Ezzat, S.

AU - Grossman, A.

AU - Ikeda, H.

AU - Inoshita, N.

AU - Karavitaki, N.

AU - Korbonits, M.

AU - Laws, E. R.

AU - Lopes, M. B.

AU - Maartens, N.

AU - McCutcheon, I. E.

AU - Mete, O.

AU - Nishioka, H.

AU - Raverot, G.

AU - Roncaroli, F.

AU - Saeger, W.

AU - Syro, L. V.

AU - Vasiljevic, A.

AU - Villa, C.

AU - Wierinckx, A.

AU - Trouillas, J.

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AB - The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

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From pituitary adenoma to pituitary neuroendocrine tumor (pitnet): An international pituitary pathology club proposal

Abstract

Keywords

ASJC Scopus subject areas

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