Abstract
Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
Original language | English (US) |
---|---|
Pages (from-to) | 601-610 |
Number of pages | 10 |
Journal | Sheng li xue bao : [Acta physiologica Sinica] |
Volume | 63 |
Issue number | 6 |
State | Published - Dec 25 2011 |
ASJC Scopus subject areas
- General Medicine