Functional Imaging Evidence of Tumor Response to High-Specific-Activity 131I-MIBG Therapy in an 84-Year-Old Patient with Metastatic Pheochromocytoma/Paraganglioma

Camilo Jimenez; Yang Lu

doi:10.1097/RLU.0000000000004519

Functional Imaging Evidence of Tumor Response to High-Specific-Activity ¹³¹I-MIBG Therapy in an 84-Year-Old Patient with Metastatic Pheochromocytoma/Paraganglioma

Camilo Jimenez, Yang Lu

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An 84-year-old man with history of metastatic pheochromocytoma/paraganglioma (mPPGL) received surgery 13 years ago, with recent biopsy-proven mPPGL in the T11. 123I-MIBG scan showed MIBG-Avid liver and osseous. Given his medical condition and body habitus (weight, 45 kg; height, 140 cm), the patient was treated with high-specific-Activity 131I-MIBG (Azedra) 300 mCi ×2. He tolerated the medication and was totally asymptomatic. Series 123I-MIBG scan showed good responses till 22 months after the first treatment at the last visit. This is probably the oldest and smallest adult mPPGL patient treated with Azedra and with prolonged good response.

Original language	English (US)
Pages (from-to)	426-427
Number of pages	2
Journal	Clinical nuclear medicine
Volume	48
Issue number	5
DOIs	https://doi.org/10.1097/RLU.0000000000004519
State	Published - May 1 2023

Keywords

high-specific-Activity I-MIBG
metastatic paraganglioma
MIBG
SPECT/CT
tumor response

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000004519

Cite this

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title = "Functional Imaging Evidence of Tumor Response to High-Specific-Activity 131I-MIBG Therapy in an 84-Year-Old Patient with Metastatic Pheochromocytoma/Paraganglioma",

abstract = "An 84-year-old man with history of metastatic pheochromocytoma/paraganglioma (mPPGL) received surgery 13 years ago, with recent biopsy-proven mPPGL in the T11. 123I-MIBG scan showed MIBG-Avid liver and osseous. Given his medical condition and body habitus (weight, 45 kg; height, 140 cm), the patient was treated with high-specific-Activity 131I-MIBG (Azedra) 300 mCi ×2. He tolerated the medication and was totally asymptomatic. Series 123I-MIBG scan showed good responses till 22 months after the first treatment at the last visit. This is probably the oldest and smallest adult mPPGL patient treated with Azedra and with prolonged good response.",

keywords = "high-specific-Activity I-MIBG, metastatic paraganglioma, MIBG, SPECT/CT, tumor response",

author = "Camilo Jimenez and Yang Lu",

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