TY - JOUR
T1 - Functional interaction of E1AF and Sp1 in glioma invasion
AU - Jiang, Jianhai
AU - Wei, Yuanyan
AU - Shen, Jialin
AU - Liu, Dan
AU - Chen, Xiaoning
AU - Zhou, Jin
AU - Zong, Hongliang
AU - Yun, Xiaojing
AU - Kong, Xiangfei
AU - Zhang, Si
AU - Yang, Yanzhong
AU - Gu, Jianxin
PY - 2007/12
Y1 - 2007/12
N2 - Transcription factor E1AF is widely known to play critical roles in tumor metastasis via directly binding to the promoters of genes involved in tumor migration and invasion. Here, we report for the first time E1AF as a novel binding partner for ubiquitously expressed Sp1 transcription factor. E1AF forms a complex with Sp1, contributes to Sp1 phosphorylation and transcriptional activity, and functions as a mediator between epidermal growth factor and Sp1 phosphorylation and activity. Sp1 functions as a carrier bringing E1AF to the promoter region, thus activating transcription of glioma-related gene for β1,4-galactosyltransferase V (GalT V; EC 2.4.1.38). Biologically, E1AF functions as a positive invasion regulator in glioma in cooperation with Sp1 partly via up-regulation of GalT V. This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors.
AB - Transcription factor E1AF is widely known to play critical roles in tumor metastasis via directly binding to the promoters of genes involved in tumor migration and invasion. Here, we report for the first time E1AF as a novel binding partner for ubiquitously expressed Sp1 transcription factor. E1AF forms a complex with Sp1, contributes to Sp1 phosphorylation and transcriptional activity, and functions as a mediator between epidermal growth factor and Sp1 phosphorylation and activity. Sp1 functions as a carrier bringing E1AF to the promoter region, thus activating transcription of glioma-related gene for β1,4-galactosyltransferase V (GalT V; EC 2.4.1.38). Biologically, E1AF functions as a positive invasion regulator in glioma in cooperation with Sp1 partly via up-regulation of GalT V. This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors.
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U2 - 10.1128/MCB.02302-06
DO - 10.1128/MCB.02302-06
M3 - Article
C2 - 17938207
AN - SCOPUS:37549029742
SN - 0270-7306
VL - 27
SP - 8770
EP - 8782
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 24
ER -