TY - JOUR
T1 - Functional role of cellular senescence in biliary injury
AU - Meng, Luke
AU - Quezada, Morgan
AU - Levine, Phillip
AU - Han, Yuyan
AU - McDaniel, Kelly
AU - Zhou, Tianhao
AU - Lin, Emily
AU - Glaser, Shannon
AU - Meng, Fanyin
AU - Francis, Heather
AU - Alpini, Gianfranco
N1 - Publisher Copyright:
© 2015 American Society for Investigative Pathology.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Cellular senescence is a state of irreversible cell cycle arrest that has been involved in many gastrointestinal diseases, including human cholestatic liver disorders. Senescence may play a role in biliary atresia, primary sclerosing cholangitis, cellular rejection, and primary biliary cirrhosis, four liver diseases affecting cholangiocytes and the biliary system. In this review, we examine proposed mechanisms of senescence-related biliary diseases, including hypotheses associated with the senescence-associated phenotype, induction of senescence in nearby cells, and the depletion of stem cell subpopulations. Current evidence for the molecular mechanisms of senescence in the previously mentioned diseases is discussed in detail, with attention to recent advances on the role of pathways associated with senescence-associated phenotype, stress-induced senescence, telomere dysfunction, and autophagy.
AB - Cellular senescence is a state of irreversible cell cycle arrest that has been involved in many gastrointestinal diseases, including human cholestatic liver disorders. Senescence may play a role in biliary atresia, primary sclerosing cholangitis, cellular rejection, and primary biliary cirrhosis, four liver diseases affecting cholangiocytes and the biliary system. In this review, we examine proposed mechanisms of senescence-related biliary diseases, including hypotheses associated with the senescence-associated phenotype, induction of senescence in nearby cells, and the depletion of stem cell subpopulations. Current evidence for the molecular mechanisms of senescence in the previously mentioned diseases is discussed in detail, with attention to recent advances on the role of pathways associated with senescence-associated phenotype, stress-induced senescence, telomere dysfunction, and autophagy.
UR - http://www.scopus.com/inward/record.url?scp=84925115565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925115565&partnerID=8YFLogxK
U2 - 10.1016/j.ajpath.2014.10.027
DO - 10.1016/j.ajpath.2014.10.027
M3 - Review article
C2 - 25619959
AN - SCOPUS:84925115565
SN - 0002-9440
VL - 185
SP - 602
EP - 609
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -