TY - JOUR
T1 - Fundamental Principles of Cancer Biology
T2 - Does It Have Relevance to the Perioperative Period?
AU - Jiang, Li
AU - Nick, Alpa M.
AU - Sood, Anil K.
N1 - Publisher Copyright:
© 2015, Springer Science + Business Media New York.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Malignant tumors are characterized by their ability to metastasize, which is the main cause of cancer-related mortality. Besides intrinsic alternations in cancer cells, the tumor microenvironment plays a pivotal role in tumor growth and metastasis. Ample evidence suggests that the perioperative period and the excision of the primary tumor can promote the development of metastases and can influence long-term cancer patient outcomes. The role of cancer biology and its impact on the perioperative period are of increasing interest. This review will present evidence regarding fundamental principles of cancer biology, especially tumor microenvironment, and discuss new therapeutic opportunities in the perioperative timeframe. We will also discuss the regulatory signaling that could be relevant to various aspects of surgery and surgical responses, which could facilitate the metastatic process by directly or indirectly affecting malignant tissues and the tumor microenvironment. We address the influences of surgery-related stress, anesthetic and analgesic agents, blood transfusion, hypothermia, and β-adrenergic blockade administration on tumor growth and metastasis. Through an improved understanding of these processes, we will provide suggestions for potential new perioperative approaches aimed at improving treatment outcomes of cancer patients.
AB - Malignant tumors are characterized by their ability to metastasize, which is the main cause of cancer-related mortality. Besides intrinsic alternations in cancer cells, the tumor microenvironment plays a pivotal role in tumor growth and metastasis. Ample evidence suggests that the perioperative period and the excision of the primary tumor can promote the development of metastases and can influence long-term cancer patient outcomes. The role of cancer biology and its impact on the perioperative period are of increasing interest. This review will present evidence regarding fundamental principles of cancer biology, especially tumor microenvironment, and discuss new therapeutic opportunities in the perioperative timeframe. We will also discuss the regulatory signaling that could be relevant to various aspects of surgery and surgical responses, which could facilitate the metastatic process by directly or indirectly affecting malignant tissues and the tumor microenvironment. We address the influences of surgery-related stress, anesthetic and analgesic agents, blood transfusion, hypothermia, and β-adrenergic blockade administration on tumor growth and metastasis. Through an improved understanding of these processes, we will provide suggestions for potential new perioperative approaches aimed at improving treatment outcomes of cancer patients.
KW - Cancer biology
KW - Perioperative
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=84987766850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84987766850&partnerID=8YFLogxK
U2 - 10.1007/s40140-015-0122-9
DO - 10.1007/s40140-015-0122-9
M3 - Article
C2 - 26388704
AN - SCOPUS:84987766850
SN - 2167-6275
VL - 5
SP - 250
EP - 256
JO - Current Anesthesiology Reports
JF - Current Anesthesiology Reports
IS - 3
ER -