Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

Robert J. Sherertz; Stephen O. Heard; I. Issam Raad; Lane Gentry; David Bowton; Philip Scuderi; Jean Hu; William Carruth; Bhagyalaxmi Satishchandra; Judith Pepe; Anne Mosenthal; Thomas Burke; Jacques Dupuis

doi:10.1128/aac.40.9.1995

Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

Robert J. Sherertz, Stephen O. Heard, I. Issam Raad, Lane Gentry, David Bowton, Philip Scuderi, Jean Hu, William Carruth, Bhagyalaxmi Satishchandra, Judith Pepe, Anne Mosenthal, Thomas Burke, Jacques Dupuis

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.

Original language	English (US)
Pages (from-to)	1995-1997
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	40
Issue number	9
DOIs	https://doi.org/10.1128/aac.40.9.1995
State	Published - Sep 1996

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.40.9.1995

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Sherertz, R. J., Heard, S. O., Raad, I. I., Gentry, L., Bowton, D., Scuderi, P., Hu, J., Carruth, W., Satishchandra, B., Pepe, J., Mosenthal, A., Burke, T., & Dupuis, J. (1996). Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients. Antimicrobial agents and chemotherapy, 40(9), 1995-1997. https://doi.org/10.1128/aac.40.9.1995

Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients. / Sherertz, Robert J.; Heard, Stephen O.; Raad, I. Issam et al.
In: Antimicrobial agents and chemotherapy, Vol. 40, No. 9, 09.1996, p. 1995-1997.

Research output: Contribution to journal › Article › peer-review

Sherertz, RJ, Heard, SO, Raad, II, Gentry, L, Bowton, D, Scuderi, P, Hu, J, Carruth, W, Satishchandra, B, Pepe, J, Mosenthal, A, Burke, T & Dupuis, J 1996, 'Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients', Antimicrobial agents and chemotherapy, vol. 40, no. 9, pp. 1995-1997. https://doi.org/10.1128/aac.40.9.1995

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abstract = "In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.",

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AU - Gentry, Lane

AU - Bowton, David

AU - Scuderi, Philip

AU - Hu, Jean

AU - Carruth, William

AU - Satishchandra, Bhagyalaxmi

AU - Pepe, Judith

AU - Mosenthal, Anne

AU - Burke, Thomas

AU - Dupuis, Jacques

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Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

Abstract

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