Gastric cancer, version 2.2013

Jaffer A. Ajani; David J. Bentrem; Stephen Besh; Thomas A. D'Amico; Prajnan Das; Crystal Denlinger; Marwan G. Fakih; Charles S. Fuchs; Hans Gerdes; Robert E. Glasgow; James A. Hayman; Wayne L. Hofstetter; David H. Ilson; Rajesh N. Keswani; Lawrence R. Kleinberg; W. Michael Korn; A. Craig Lockhart; Kenneth Meredith; Mary F. Mulcahy; Mark B. Orringer; James A. Posey; Aaron R. Sasson; Walter J. Scott; Vivian E. Strong; Thomas K. Varghese; Graham Warren; Mary Kay Washington; Christopher Willett; Cameron D. Wright; Nicole R. McMillian; Hema Sundar

doi:10.6004/jnccn.2013.0070

Gastric cancer, version 2.2013

Jaffer A. Ajani, David J. Bentrem, Stephen Besh, Thomas A. D'Amico, Prajnan Das, Crystal Denlinger, Marwan G. Fakih, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Wayne L. Hofstetter, David H. Ilson, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, A. Craig Lockhart, Kenneth Meredith, Mary F. Mulcahy, Mark B. OrringerJames A. Posey, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese, Graham Warren, Mary Kay Washington, Christopher Willett, Cameron D. Wright, Nicole R. McMillian, Hema Sundar

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Abstract

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+.

Original language	English (US)
Pages (from-to)	531-546
Number of pages	16
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	11
Issue number	5
DOIs	https://doi.org/10.6004/jnccn.2013.0070
State	Published - May 1 2013

ASJC Scopus subject areas

Oncology

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Ajani, J. A., Bentrem, D. J., Besh, S., D'Amico, T. A., Das, P., Denlinger, C., Fakih, M. G., Fuchs, C. S., Gerdes, H., Glasgow, R. E., Hayman, J. A., Hofstetter, W. L., Ilson, D. H., Keswani, R. N., Kleinberg, L. R., Korn, W. M., Lockhart, A. C., Meredith, K., Mulcahy, M. F., ... Sundar, H. (2013). Gastric cancer, version 2.2013. JNCCN Journal of the National Comprehensive Cancer Network, 11(5), 531-546. https://doi.org/10.6004/jnccn.2013.0070

Ajani, JA, Bentrem, DJ, Besh, S, D'Amico, TA, Das, P, Denlinger, C, Fakih, MG, Fuchs, CS, Gerdes, H, Glasgow, RE, Hayman, JA, Hofstetter, WL, Ilson, DH, Keswani, RN, Kleinberg, LR, Korn, WM, Lockhart, AC, Meredith, K, Mulcahy, MF, Orringer, MB, Posey, JA, Sasson, AR, Scott, WJ, Strong, VE, Varghese, TK, Warren, G, Washington, MK, Willett, C, Wright, CD, McMillian, NR & Sundar, H 2013, 'Gastric cancer, version 2.2013', JNCCN Journal of the National Comprehensive Cancer Network, vol. 11, no. 5, pp. 531-546. https://doi.org/10.6004/jnccn.2013.0070

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abstract = "The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+.",

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AU - Fakih, Marwan G.

AU - Fuchs, Charles S.

AU - Gerdes, Hans

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AU - Hofstetter, Wayne L.

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AU - Lockhart, A. Craig

AU - Meredith, Kenneth

AU - Mulcahy, Mary F.

AU - Orringer, Mark B.

AU - Posey, James A.

AU - Sasson, Aaron R.

AU - Scott, Walter J.

AU - Strong, Vivian E.

AU - Varghese, Thomas K.

AU - Warren, Graham

AU - Washington, Mary Kay

AU - Willett, Christopher

AU - Wright, Cameron D.

AU - McMillian, Nicole R.

AU - Sundar, Hema

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Gastric cancer, version 2.2013

Abstract

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