TY - JOUR
T1 - Gastric-type mucinous adenocarcinoma of the uterine cervix with neoadjuvant therapy mimicking clear cell carcinoma
AU - Zhang, Yifen
AU - Liang, Li
AU - Euscher, Elizabeth D.
AU - Liu, Jinsong
AU - Ramalingam, Preetha
N1 - Funding Information:
This work was supported in part by grant from the Cancer Prevention and Research Institute of Texas, the MD Anderson Cancer Center SPORE in Ovarian Cancer (National Institutes of Health grant), a Sister Institution Grant from MD Anderson Cancer Center Global Academic Programs.
PY - 2015
Y1 - 2015
N2 - Gastric-type mucinous adenocarcinoma, an uncommon subtype of cervical carcinoma, is characterized by a distinct morphology and immunophenotype. Herein, we report a case of a 71-year-old woman who received neoadjuvant radiotherapy and chemotherapy after cervical biopsy revealed moderately differentiated invasive endocervical adenocarcinoma. Subsequently, the outside patient underwent radical hysterectomy with bilateral salpingo-oophorectomy. The post-neoadjuvant therapy hysterectomy specimen showed tumor cells with clear cytoplasm, hyperchromatic nuclei with irregular contours, which mimicked clear cell carcinoma. However, immunohistochemical staining showed that these tumor cells were positive for carcinoembryonic antigen, cytokeratin 7 (diffuse), and cytokeratin 20 (patchy), After review of the pretreatment cervical biopsy specimen, the tumor was favored to represent a gastric-type mucinous adenocarcinoma of the cervix. Pathologists should be aware of this rare tumor and its post-neoadjuvant therapy morphologic changes, which can make diagnosis more challenging.
AB - Gastric-type mucinous adenocarcinoma, an uncommon subtype of cervical carcinoma, is characterized by a distinct morphology and immunophenotype. Herein, we report a case of a 71-year-old woman who received neoadjuvant radiotherapy and chemotherapy after cervical biopsy revealed moderately differentiated invasive endocervical adenocarcinoma. Subsequently, the outside patient underwent radical hysterectomy with bilateral salpingo-oophorectomy. The post-neoadjuvant therapy hysterectomy specimen showed tumor cells with clear cytoplasm, hyperchromatic nuclei with irregular contours, which mimicked clear cell carcinoma. However, immunohistochemical staining showed that these tumor cells were positive for carcinoembryonic antigen, cytokeratin 7 (diffuse), and cytokeratin 20 (patchy), After review of the pretreatment cervical biopsy specimen, the tumor was favored to represent a gastric-type mucinous adenocarcinoma of the cervix. Pathologists should be aware of this rare tumor and its post-neoadjuvant therapy morphologic changes, which can make diagnosis more challenging.
KW - Clear cell carcinoma
KW - Endocervical adenocarcinoma
KW - Gastric-type
KW - Neoadjuvant therapy
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M3 - Article
C2 - 26617929
AN - SCOPUS:85013304844
SN - 1936-2625
VL - 8
SP - 11798
EP - 11803
JO - International journal of clinical and experimental pathology
JF - International journal of clinical and experimental pathology
IS - 9
ER -