@article{410ac4e6d62840d98151ab761a74c5f0,
title = "Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases",
abstract = "Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett{\textquoteright}s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions.",
author = "BEACON and {23andMe Research Team} and Jiyuan An and Puya Gharahkhani and Law, {Matthew H.} and Ong, {Jue Sheng} and Xikun Han and Olsen, {Catherine M.} and Neale, {Rachel E.} and John Lai and Vaughan, {Tom L.} and B{\"o}hmer, {Anne C.} and Janusz Jankowski and Fitzgerald, {Rebecca C.} and Johannes Schumacher and Claire Palles and Gammon, {Marilie D.} and Corley, {Douglas A.} and Shaheen, {Nicholas J.} and Bird, {Nigel C.} and Hardie, {Laura J.} and Murray, {Liam J.} and Reid, {Brian J.} and Chow, {Wong Ho} and Risch, {Harvey A.} and Weimin Ye and Geoffrey Liu and Yvonne Romero and Leslie Bernstein and Wu, {Anna H.} and M. Agee and B. Alipanahi and A. Auton and Bell, {R. K.} and K. Bryc and Elson, {S. L.} and P. Fontanillas and Furlotte, {N. A.} and Hinds, {D. A.} and Huber, {K. E.} and A. Kleinman and Litterman, {N. K.} and McIntyre, {M. H.} and Mountain, {J. L.} and Noblin, {E. S.} and Northover, {C. A.M.} and Pitts, {S. J.} and Sathirapongsasuti, {J. Fah} and Sazonova, {O. V.} and Shelton, {J. F.} and S. Shringarpure and C. Tian",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-11968-2",
language = "English (US)",
volume = "10",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}