Abstract
Although gastrointestinal cytomegalovirus disease (GI-CMVd) is not common in cancer patients, it is associated with high morbidity and mortality. Herein, we review our 2-decade experience with GI-CMVd in such patient population at The University of Texas M.D. Anderson Cancer Center. Forty-seven patients were identified. Thirty-four patients (72%) had an underlying haematological malignancy, and 18 patients (38%) developed GI-CMVd following hematopoietic stem cell transplantation (HSCT). Nine (25%) of the 36 cancer patients with data available had AIDS. Upper-GI tract involvement was more common in patients with haematological malignancies than in those with solid tumours (P = 0.02). Patients with AIDS were more likely to have colonic involvement than were those without AIDS (67% vs. 15%, P = 0.006), and patients without AIDS were more likely to have gastric involvement (59% vs. 11%, P = 0.01). The CMV-attributable mortality rate was 42%. Independent predictors of death by multivariate analysis included disseminated CMV and AIDS (P < 0.01). The presentation of GI-CMVd varies according to the type of cancer, and AIDS. GI-CMVd is associated with a high mortality among cancer patients, particularly those with disseminated CMV disease or AIDS.
Original language | English (US) |
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Pages (from-to) | 2268-2279 |
Number of pages | 12 |
Journal | European Journal of Cancer |
Volume | 41 |
Issue number | 15 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- AIDS
- BMT
- Cancer
- Colitis
- Cytomegalovirus
- Gastritis
- HIV
- HSCT
ASJC Scopus subject areas
- Oncology
- Cancer Research